Kaitlyn D’Onofrio

DocwireNews

A recent study published in Arthritis Research &amp; Therapy assessed the risk of comorbidities among patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA).Researchers matched 408 consecutive SSc patients (mean age, 59 years; 87% female) 1:1 for age and gender with 408 RA patients; mean disease duration was 10 years for SSc and 9 years for RA.Between the two groups, there was no difference in arterial hypertension or smoking. However, SSc patients had lower dyslipidemia rates (18.4% vs 30.1%, p&thinsp;=&thinsp;0.001), diabetes mellitus rates (5.6% vs 11.8%, p&thinsp;=&thinsp;0.007), body mass index (P=0.001), and ischemic stroke rates (1.1% vs 3.2%, p&thinsp;=&thinsp;0.085) than RA patients. SSc patients and RA patients had similar rates of chronic obstructive pulmonary disease (5.2% vs 3.7%), osteoporosis (24% vs 22%), overall neoplasms (1.1% vs 1.7%), and coronary artery disease (2.7% vs 3.7%). While cancer rates were similar between the groups, types of cancers differed: in the SSc group, lung cancer was the most common (7/17, 41%), while RA patients were more likely to have hematologic malignancies (7/19, 36%) or breast cancer (7/19, 36%). SSc patients were more likely to have depression (22% vs 12%, p&thinsp;=&thinsp;0.001) than RA patients.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Prevalence of comorbidities in systemic sclerosis vs RA: SSc has comparable cardiovascular risk to RA but poses a greater negative impact on quality of life, as more patients with SSc develop depression <a href="https://twitter.com/hashtag/rheumatoidarthritis?src=hash&amp;ref_src=twsrc%5Etfw">#rheumatoidarthritis</a> <a href="https://twitter.com/hashtag/systemicsclerosis?src=hash&amp;ref_src=twsrc%5Etfw">#systemicsclerosis</a> <a href="https://twitter.com/hashtag/depression?src=hash&amp;ref_src=twsrc%5Etfw">#depression</a> <a href="https://t.co/8IwkQwsO3d">https://t.co/8IwkQwsO3d</a>
&mdash; Reumatolog&iacute;a Clinic (@Reumaclinic) <a href="https://twitter.com/Reumaclinic/status/1070279485797347329?ref_src=twsrc%5Etfw">December 5, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>&ldquo;Despite the prevalence of dyslipidemia and diabetes mellitus in SSc being almost half that in RA, the cardiovascular comorbidity burden appears to be similar in both,&rdquo; the researchers wrote. &ldquo;The overall prevalence of neoplasms is no higher in SSc than in RA, but SSc has a more negative impact on quality of life, as clearly, more SSc patients develop depression compared to patients with RA.&rdquo;<a href="https://proddocwire.wpengine.com/docwire-pick/systemic-sclerosis-systemic-lupus/">Analysis: Systemic Sclerosis and Systemic Lupus Erythematous Overlap</a><a href="https://proddocwire.wpengine.com/abstracts/epidemiology-and-survival-of-systemic-sclerosis-systemic-lupus-erythematosus-overlap-syndrome/">Epidemiology and Survival of Systemic Sclerosis-Systemic Lupus Erythematosus Overlap Syndrome</a><a href="https://proddocwire.wpengine.com/docwire-pick/rheumatology-picks/study-strong-reproducibility-in-6-minute-walk-test-for-systemic-sclerosis/">Study: Strong Reproducibility in 6-Minute Walk Test for Systemic Sclerosis</a><a href="https://proddocwire.wpengine.com/abstracts/evolving-symptoms-of-raynauds-phenomenon-in-systemic-sclerosis-are-associated-with-physician-and-patient%E2%80%90reported-assessments-of-disease-severity/">Evolving symptoms of Raynaud&rsquo;s phenomenon in systemic sclerosis are associated with physician and patient&#8208;reported assessments of disease severity</a>Source: <a href="https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-018-1771-0">Arthritis Research &amp; Therapy</a>

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A recent study published in Arthritis Research &amp; Therapy assessed the risk of comorbidities among patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA).
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