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Despite recent advancements in immuno-oncology, not all patients with cancer benefit from current treatments, and additional therapeutic options are needed for both hematologic malignancies and solid tumors.1Cytotoxic T-cells play an important role in identifying and eliminating cancer cells;2 however, cancer cells can develop mechanisms to evade T-cell recognition and destruction.1 Bispecific T-cell engager (BiTE&reg;) technology engages the patient&rsquo;s T-cells to directly target cancer cells to engage and attack cancer cells that may have previously learned to evade or escape these mechanisms. BiTE&reg; molecules are engineered from two flexibly linked, single-chain antibodies&mdash;one that is specific for a selected tumor-antigen and the other that is specific for CD3 found on T-cells.2,3Learn more about the BiTE&reg; immuno-oncology platform and the goal of enhancing cancer treatment in a video presented by Amgen.References<ol>
<li>Alatrash G, Jakher H, Stafford PD, et al. Expert Opin Drug Saf. 2013;12:631-45.</li>
<li>Baeuerle PA, Kufer P, Bargou R. Curr Opin Mol Ther. 2009;11:22-30.</li>
<li>Yuraszeck T, Kasichayanula S, Benjamin JE. Clin Pharmacol Ther. 2017;101:634-45.</li>
</ol>

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Despite recent advancements in immuno-oncology, not all patients with cancer benefit from current treatments, and additional therapeutic options are needed for both ...

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