Despite recent advancements in immuno-oncology, not all patients with cancer benefit from current treatments, and additional therapeutic options are needed for both hematologic malignancies and solid tumors.1
Cytotoxic T-cells play an important role in identifying and eliminating cancer cells;2 however, cancer cells can develop mechanisms to evade T-cell recognition and destruction.1 Bispecific T-cell engager (BiTE®) technology engages the patient’s T-cells to directly target cancer cells to engage and attack cancer cells that may have previously learned to evade or escape these mechanisms. BiTE® molecules are engineered from two flexibly linked, single-chain antibodies—one that is specific for a selected tumor-antigen and the other that is specific for CD3 found on T-cells.2,3
Learn more about the BiTE® immuno-oncology platform and the goal of enhancing cancer treatment in a video presented by Amgen.
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