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A study published in <a href="https://link.springer.com/article/10.1007%2Fs00520-018-4513-6">Supportive Care in Cancer</a> confirmed guideline-indicated recommendations for timing on initiating granulocyte colony-stimulating factors (G-CSFs) to management chemotherapy-induced neutropenia (CIN) and febrile neutropenia. Despite current guidelines recommending G-CSF within 24 to 72 hours following chemotherapy, some studies have indicated that G-CSF given less than 24 hours after chemotherapy may benefit some patients; thus, the researchers conducted the prospective, observational, multicenter, pan-European MONITOR-GCSF study.Investigators assessed 1,447 chemotherapy-treated patients who received daily biosimilar filgrastim-sndz and classified them based on G-CSF initiation:<ul>
<li>same-day (initiated less than 24 hours after chemotherapy)</li>
<li>per-guidelines (initiated 24 to 72 hours after chemotherapy)</li>
<li>late (initiated more than 72 hours after chemotherapy)</li>
</ul>Among 1,423 evaluable patients, there were 5,930 chemotherapy cycles, including 795 cycles classified as same-day (13.4%), 3,320 classified as per-guidelines (56.0%), and 1,815 classified as late (30.6%).There did not appear to be differences among the groups with regard to CIN grade 1 or 4 or febrile neutropenia episodes. There were also no differences in CIN- or febrile neutropenia-related hospitalizations or disruptions in chemotherapy schedules.Patients in the same-day and per-guidelines groups had statistically similar odds of not experiencing CIN or febrile neutropenia in any given treatment cycle. Patients in the late group had worse odds of experiencing CIN grade 1 or 4, CIN grade 3 or 4, and CIN grade 4 episodes during any treatment cycle.The researchers concluded that filgrastim given within 24 to 72 hours after chemotherapy is &ldquo;effective and safe,&rdquo; but filgrastim administration on the same day as chemotherapy (within 24 hours) may be appropriate for some patients.

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Initiation of Biosimilar Filgrastim Within 24-72 Hours of Chemotherapy Reduces Neutropenia

Oncology

A study published in Supportive Care in Cancer confirmed guideline-indicated recommendations for timing on initiating granulocyte colony-stimulating factors (G-CSFs) to ...

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