DocWire News Editors

DocwireNews

Relapsing&nbsp;polychondritis&nbsp;(RP)&nbsp;is&nbsp;a rare disease which involved recurrent inflammation of cartilage and other tissues. This disease is painful and can cause joint deformity but can also be lethal if areas such as the blood vessels are affected.&nbsp;In this&nbsp;French multicenter&nbsp;retrospective cohort study&nbsp;in&nbsp;Annals of the Rheumatic Diseases,&nbsp;researchers aimed to assess the safety and efficacy of biologics on patients with RP.&nbsp;<a href="https://twitter.com/ReumaHUSC/status/1017449215658688512">https://twitter.com/ReumaHUSC/status/1017449215658688512</a>According to the study, efficacy outcomes were clinical response (partial or complete) and complete response during the first 6 months of exposure, plus daily corticosteroid dose at 6 months.&nbsp;Forty-one patients were on 105 biologics in the study&nbsp;(tumor-necrosis factor&nbsp;[TNF]&nbsp;inhibitors, n=60; tocilizumab, n=17; anakinra, n=15; rituximab, n=7; abatacept, n=6).&nbsp;The overall response rate&nbsp;of patients&nbsp;during the first 6 months of exposure was 62.9%, with&nbsp;a&nbsp;complete response rate&nbsp;of&nbsp;19.0%.&nbsp;Adverse drug reactions&nbsp;(ADRs) consisted mostly of infection (n=42).&nbsp;The seasons for biologic withdrawal were insufficient efficacy, loss of efficacy, and ADRs.&nbsp;Although the study&rsquo;s focus was the efficacy and safety of biologics for RP, &ldquo;the number of complete responses was low and there were concerns about the risk of ADRs, particularly infections,&rdquo; the researchers concluded.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
ADA works better and ETA has significant withdrawal rates <a href="https://twitter.com/hashtag/Relapsing?src=hash&amp;ref_src=twsrc%5Etfw">#Relapsing</a> polychondritis <a href="https://t.co/4hluSyLE2S">https://t.co/4hluSyLE2S</a>
&mdash; Rajkiran Dudam (@RajkiranDudam) <a href="https://twitter.com/RajkiranDudam/status/994805841458094081?ref_src=twsrc%5Etfw">May 11, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>SOURCE:&nbsp;<a href="https://ard.bmj.com/content/77/8/1172">Annals of the Rheumatic Diseases&nbsp;</a>

Jordana Jampel

Distant Brain Metastases in Cutaneous Melanoma May Be Mitigated With Multiple Pathway Inhibitors

Melanoma

Eric Bergson, MD

Rob Dillard

The Role of Multidisciplinary Care in Head and Neck Cancer

Head and Neck Cancer

Sara Nunnery, MD, MSCI

Trastuzumab Deruxtecan in HER2-Low Breast Cancer: Who’s the Right Patient?

HER2 Breast Cancer

Latest News

Biologics in Relapsing Polychondritis

Rheumatology

Relapsing polychondritis (RP) is a rare disease which involved recurrent inflammation of cartilage and other tissues. This disease is painful and can cause joint deformity ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe