DocWire News Editors

DocwireNews

First-line treatment with bortezomib (B) plus dexamethasone, rituximab, and cyclophosphamide (DRC) was well tolerated and associated with deep remissions and prolonged progression-free survival (PFS) in patients with Waldenstrom macroglobulinemia (WM), according to results from a phase II trial.Christian Buske, MD, of the University Hospital Ulm in Germany presented results from the trial =at the 62nd American Society of Hematology Annual Meeting &amp; Exposition. In the trial, a total of 204 patients with WM were randomized to either DRC or B-DRC. The primary endpoint was PFS, and the secondary endpoints were response rates, overall survival (OS), and toxicity.The median age of the study population was 68 years in both treatment arms. Overall, the median follow-up duration was 27.5 months at time of data cutoff. Approximately 73% of patients in both treatment arms were at intermediate risk, according to the International Prognostic Scoring System for WM, whereas 13% of patients in both arms were at high risk.At time of data cutoff, the median PFS in the B-DRC arm had not been reached. In the DRC arm, the median PFS was 50.1 months. The estimated 24-month PFS rates were 80.6 % for the B-DRC group and 72.8% for the DRC arm.Although B-DRC was associated with prolonged PFS, it was not significantly different than DRC alone. &ldquo;Future trials will have to compare chemotherapy-free approaches such as continuous treatment with Bruton&rsquo;s tyrosine kinase inhibitors with fixed duration treatments exemplified by B-DRC to understand which of the two treatment approaches offers the highest long-term sustained clinical benefit to [patients with] WM,&rdquo; the researchers noted.The median OS had not been reached in either treatment arm. There were five reported deaths in the B-DRC group and six in the DRC arm. At the end of treatment, B-DRC was associated with major responses in 79% of patients. In contrast, major responses were observed in 68.9% of patients randomized to DRC. The overall response rates were 91.2% for B-DRC versus 86.7% for DRC.Both treatments were well tolerated, with grade &ge;3 adverse events (AEs) observed in 48% of patients overall. The most common grade &ge;3 AEs included neutropenia (25%), anemia (6%), and thrombocytopenia (5%).

MarkAlain Déry, DO

Eric Griggs, MD

Measles in America: An Ongoing Problem

Infectious Disease

Roger Rodby, MD

Joel M. Topf, MD, FACP

Seldin Award Winner Advocates Online Education

NKF Spring Clinical Meetings 2025

Hatem Soliman, MD

The Future of Dendritic Cell Vaccines in HER2+ Breast Cancer: Toward De-Escalation of Chemotherapy

HER2 Breast Cancer

Latest News

B-DRC Produces Deep Remissions, Clinically Meaningful PFS Rates in Patients with Waldenstrom Macroglobulinemia

ASH Annual Meeting 2020

First-line treatment with bortezomib (B) plus dexamethasone, rituximab, and cyclophosphamide (DRC) was well tolerated and associated with deep remissions and prolonged ...

B-DRC Produces Deep Remissions, Clinically Meaningful PFS Rates in Patients with Waldenstrom

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe