Rob Dillard

DocwireNews

The use of colored avocado seed extract (CASE), developed from crushed avocado seeds, displayed anti-inflammatory properties that can be used as either functional food ingredients or as lead compounds for pharmaceutical development, according to Penn State researchers who published their <a href="https://openventio.org/wp-content/uploads/Anti-Inflammatory-Properties-of-a-Colored-Avocado-Seed-Extract-AFTNSOJ-5-151.pdf">findings</a> in Advances In Food Technology And Nutritional Sciences.Avocados are known to be rich in essential nutrients such as unsaturated fatty acids, fiber, and vitamins B and E. Researchers of this study previously reported that the avocado seed, when crushed, produces a bright orange extract that can potentially be used as a food additive to alleviate inflammation.In this laboratory study, Lipopolysaccharide (LPS)-simulated RAW2647 murine macrophage cells were treated with CASE for a 24-hour duration, and subsequently the pro-inflammatory cytokines, Interluekin -6 (IL-6), tumor necrosis factor-&alpha; (TNF-&alpha;) and IL-1&beta; (Interleukin -1&beta;) were measured along with nitric oxide (NO) production. The researchers also examined if CASE would inhibit the activity of secreted Phospholipase A2 (PLA2) while evaluating the extract&rsquo;s effect on Cyclooxygenase -2 (COX-2) and prostaglandin E2 (PGE2).<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Avocado seed extract shows promise as anti-inflammatory compound &ndash; Science&nbsp;Daily <a href="https://t.co/XBsPlGmTEq">https://t.co/XBsPlGmTEq</a>
&mdash; Food Educator (@FoodEducator) <a href="https://twitter.com/FoodEducator/status/1106028702587125760?ref_src=twsrc%5Etfw">March 14, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><h2>Extract Exhibits Great Promise</h2>According to the study results, the treatment of LPS-stimulated RAW264.7 cells with CASE over 24-hours diminished the production of pro-inflammatory cytokines, IL-6, TNF-&alpha;, and IL-1&beta; while NO production was mitigated in a dose-dependent manner, and the reduction was associated with a decrease in the protein expression of inducible nitric oxide synthase (iNOS). Moreover, PGE2 production was significantly reduced by CASE while no deviation in the protein expression of Cyclooxygenase -2 (COX-2) was observed. Furthermore, CASE impeded the activity of purified secreted PLA2 (IC50=36 &mu;g/mL), and kinetic analysis suggested that the inhibition was non-competitive with respect to substrate concentration. Nuclear translocation of nuclear factor &kappa;B (NF-kB) to the nucleus was also reduced by treatment with CASE, and this inhibition may underscore the effects of CASE on iNOS and cytokine expression.&ldquo;The level of activity that we see from the extract is very good,&rdquo; said Dr. Joshua Lambert, co-director of Penn State&rsquo;s Center for Plant and Mushroom Foods for Health, in a <a href="https://www.eurekalert.org/pub_releases/2019-03/ps-ase031319.php">press release</a> about the study. &ldquo;We saw inhibitory activity at concentrations in the low microgram-per-milliliter range, which is an acceptable amount of activity to justify further studies.&rdquo;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Avocado seed extract shows promise as anti-inflammatory compound <a href="https://t.co/moEpF5GaMd">https://t.co/moEpF5GaMd</a> <a href="https://t.co/Bf3rVJ4lvD">pic.twitter.com/Bf3rVJ4lvD</a>
&mdash; Andy Vermaut (@AndyVermaut) <a href="https://twitter.com/AndyVermaut/status/1105896948953837568?ref_src=twsrc%5Etfw">March 13, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Dr. Lambert, and colleagues have filed a patent application for the use of the extract as a food color additive.&ldquo;If we can return value to avocado growers or avocado processors, that would be a benefit, and if we can reduce the amount of this material being dumped in landfills, that would be a good thing, given the huge amount of avocados that are consumed,&rdquo; he said. &ldquo;This is encouraging because there is a market for other high-value sources of bioactive compounds we have tested in my lab, such as cocoa and green tea &ndash; whereas avocado seeds are essentially considered to be garbage.&rdquo;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Avocado seed extract shows promise as anti-inflammatory compound <a href="https://t.co/NlV7XC8MYi">https://t.co/NlV7XC8MYi</a> <a href="https://t.co/pLyUaT4ld4">pic.twitter.com/pLyUaT4ld4</a>
&mdash; ScienceBlog.com (@ScienceBlogTwit) <a href="https://twitter.com/ScienceBlogTwit/status/1105549320596668417?ref_src=twsrc%5Etfw">March 12, 2019</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>

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Avocado Seed Extract Displays Anti-Inflammatory Properties

Diet

The use of colored avocado seed extract (CASE), developed from crushed avocado seeds, displayed anti-inflammatory properties that can be used as either functional food ...

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