Cailin Conner

DocwireNews

Asymptomatic hyperuricemia, a significant risk factor for gout, was found to be associated with an increased risk of developing nephrolithiasis (kidney stones).The study, published in <a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-16469-y" target="_blank" rel="noopener">BMC Public Health</a>, included 22,303 patients aged 30 to 79 years. Investigators employed standardized face-to-face interviews, medical examinations, and biochemical tests to collect data. Their primary objective was to explore &ldquo;whether hyperuricemia itself or serum uric acid (SUA) is related to the risk of nephrolithiasis.&rdquo;Researchers used logistic regression analysis to estimate the relationship between hyperuricemia and nephrolithiasis and a restricted cubic spline (RCS) model to explore the dose-response relationship between SUA levels and the risk of nephrolithiasis.Among the patients included in the study, 14.5% had hyperuricemia and 12.1% were diagnosed with nephrolithiasis. After accounting for various potential confounding factors, the researchers discovered a significant association between hyperuricemia and the risk of developing nephrolithiasis. Patients with hyperuricemia were found to have an odds ratio of 1.464 (95% CI, 1.312-1.633; P&lt;.001) compared with those without hyperuricemia.The RCS analysis revealed that as SUA levels increased, so did the risk of nephrolithiasis. This dose-response relationship was consistent in both males and females. In males, the risk of nephrolithiasis increased when SUA levels exceeded 356 &mu;mol/L, while in females, the threshold was 265 &mu;mol/L.&ldquo;Before reaching the diagnostic criteria for hyperuricemia, the risk of nephrolithiasis rises with the increase in SUA,&rdquo; the investigators concluded. &ldquo;This [finding] suggests that controlling SUA levels may be significant for the prevention of nephrolithiasis.&rdquo;

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Asymptomatic Hyperuricemia Associated With Increased Risk of Kidney Stones

Gout

Asymptomatic hyperuricemia is independently associated with an increased risk of developing kidney stones, with a dose-response relationship between serum uric acid level and risk.

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