Rob Dillard

DocwireNews

A study analyzed the correlation between cancer-related cognitive impairment (CRCI) in patients taking chemotherapy for breast, gastrointestinal, gynecological, or lung cancer and neurotransmission pathways. The findings were <a href="https://pubmed.ncbi.nlm.nih.gov/39325169/" target="_blank" rel="noopener">reported</a> in the Journal of Neural Transmission.&nbsp;In this study, researchers assessed 508 patients who completed the Attentional Function Index six times over two cycles of chemotherapy. They quantified gene expression using either ribonucleic (RNA)-sequencing or microarray analyses and pathway impact analyses.According to the results, of 261 patients in the RNA-sequencing sample, almost half (48.7%) were in the High class and over half (51.3%) were in the Low class. Of the 247 patients the microarray sample, 46.6% were in the High class and 53.4% were in the Low class. Overall, the analysis identified seven perturbed pathways related to neurotransmission (i.e., glutamatergic synapse, GABAergic synapse, dopaminergic synapse, serotonergic synapse, long-term depression, cholinergic synapse, retrograde endocannabinoid signaling).&ldquo;This study is the first to describe associations between self-reported CRCI in patients receiving chemotherapy for breast, gastrointestinal, gynecological, or lung cancer and seven neurotransmission pathways. These findings provide new insights into potential targets for mechanistically based interventions,&rdquo; the researchers concluded.&nbsp;

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