A study identified possible prognostic factors and survival patterns based on histology type in patients with perimenopausal endometrial carcinoma (PIPEC) treated with hysterectomy. The findings were published in Discover Oncology.
The investigators analyzed 14,178 PIPEC patients from the Surveillance, Epidemiology, and End Results (SEER) database. They used random survival forest (RSF) and Cox regression to identify possible prognostic factors of PIPEC. Subsequently, the overall survival (OS) and cancer-specific survival (CSS) of PIPEC data were analyzed by histological types with regional lymph nodes status and SEER-stage used to investigate the survival patterns of the PIPEC patients.
The results showed that tumor size, grade, histology, SEER-stage, AJCC-stage, AJCC-T stage, metastasis to distant organs and regional lymph nodes status all had a significant impact on survival outcome for PIPEC (all p < 0.05). The investigators noted that regardless of regional lymph nodes status and SEER-stage for OS and CSS, the low-grade endometrioid carcinoma had the best prognosis outcome, followed by the mix cell adenocarcinoma and high-grade endometrioid carcinoma, while the carcinosarcoma and undifferentiated carcinoma had relatively poor prognosis outcome.
“We identified the possible prognostic factors of PIPEC patients treated with hysterectomy. And survival analysis based on the regional lymph nodes status and SEER-stage revealed the different histological types of PIPEC had diverse survival patterns, which will be helpful for guiding clinical practice,” the researchers concluded.
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