Victoria Socha

DocwireNews

Researchers, led by Manpreet K. Grewal, MD, conducted a retrospective chart review to examine the prevalence and factors associated with the risk of acute kidney injury (AKI) in pediatric patients with SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C).The review included 113 patients with SARS-CoV-2 infection with and without MIS-C who were admitted at Children&rsquo;s Hospital of Michigan from March to August 2021. The final analysis included 92 patients. Of those, 24% (n=22) developed AKI, with eight of the 22 (36%) developing AKI stage 3. The prevalence of AKI was substantially higher in patients with MIS-C (54%; 15/28) than in those with acute SARS-CoV-2 infection (11%; 7/64), P&lt;.001.Overall, compared with patients without AKI, those with AKI were older (11 vs 6.5 years; P=.007), were Black (86% vs 58%; P=.0028), had a diagnosis of MIS-C (68% vs 19%; P&lt;.001), required admission to the intensive care unit (91% vs 20%; P&lt;.001), had cardiac dysfunction (63% vs 16%; P&lt;.001), required inotropic support (59% vs 6%; P&lt;.001) and had a greater elevation in inflammatory markers. In multivariable analysis, the most significant predictors for AKI were the requirement of inotropes (odds ratio [OR], 22.8; P&lt;.001), Black race (OR, 8.8; P=.023), and MIS-C diagnosis (OR, 5.3; P=.013). All of the patients had recovery of kidney function, and none required kidney replacement therapy.In conclusion, the authors said, &ldquo;Children with acute SARS-CoV-2 infection and MIS-C are at risk for AKI, with the risk being significantly greater with MIS-2. The pathogenesis of AKI in acute SARS-CoV-2 infection appears to be a combination of both renal hypoperfusion and direct renal parenchymal damage whereas in MIS-C, the renal injury appears to be predominantly prerenal from cardiac dysfunction and capillary leak from a hyperinflammatory state. These factors should be considered by clinicians caring for these children with a special focus on renal protective strategies to aid in recovery and prevent additional injury to this high-risk subgroup.&rdquo;

Jordana Jampel

Positive Preliminary Results From Phase 1 Trial of Dopaminergic Neuron Graft for Parkinson’s Disease

Dementia

Bradley Warady, MD

Joel M. Topf, MD, FACP

2025 Hume Award Winner Is Dedicated to Children’s Care

NKF Spring Clinical Meetings 2025

Distant Brain Metastases in Cutaneous Melanoma May Be Mitigated With Multiple Pathway Inhibitors

Melanoma

Latest News

AKI in Children with SARS-CoV-2 Infection with and without MIS-C

Acute Kidney Injury

Researchers, led by Manpreet K. Grewal, MD, conducted a retrospective chart review to examine the prevalence and factors associated with the risk of acute kidney injury (AKI) ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe