A Radiation Oncologist's Perspective on the PROSPECT Trial

By Chadi Nabhan, MD, MBA - Last Updated: February 2, 2024

Salma Jabbour, MD, a professor and vice-chair of radiation oncology at Rutgers Cancer Institute, joins Dr. Chadi Nabhan to provide her invaluable perspective on the PROSPECT trial, which investigated neoadjuvant therapy regimens for locally advanced rectal cancer. Dr. Jabbour delves into how radiation oncology has changed in a transformative way over the past 2 decades, contrasting its trajectory with the field of precision oncology. She shares compelling insights into the PROSPECT trial’s innovative approach of omitting radiation therapy entirely for patients with rectal cancer and emphasizes the study’s “impressive” results. Dr. Jabbour also discusses the complexities, challenges, and potential paradigm shifts these findings might signal for the field.

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