HER2-Positive Breast Cancer
Dr. Lustberg discusses DESTINY-Breast09 and the potential shift to T-DXd + pertuzumab in HER2+ mBC first-line treatment. Stephanie Graff, MD, reviews top ASCO25 breast cancer trials, including ASCENT-04, DESTINY-Breast09, and SERENA-6.
T-DXd plus pertuzumab significantly improves PFS vs THP in HER2+ mBC, per interim results from DESTINY-Breast09. THP delivers similar pCR and better tolerability than TCbHP for HER2+ early breast cancer, per phase 3 neoCARHP trial. T-DXd improves PFS and cORR over chemo in HER2-low/ultralow HR+ mBC, regardless of PI3K, ESR1, or BRCA1/2 mutations. T-DXd rechallenge after grade 1 ILD showed high success and prolonged benefit, with low recurrence and no grade 5 events. Trastuzumab rezetecan shows strong intracranial activity in HER2+ breast cancer with brain metastases in REIN trial. Pembrolizumab plus dual HER2 blockade may offer a chemo-free option for early HER2+ breast cancer, phase 2 data suggest. Enhertu plus THP improved pCR over standard chemo in high-risk HER2+ early breast cancer, DESTINY-Breast11 shows.
Dr. Soliman explores dendritic cell vaccines to boost immunity and cut chemo toxicity in early HER2-positive breast cancer. Pilot study shows HER2-targeted dendritic cell vaccines may enhance immune response in early HER2-positive breast cancer. Enhertu plus pertuzumab significantly improved PFS vs. THP in 1L HER2+ mBC, marking the first advance in over a decade. The CDK4/6 inhibitor showed meaningful improvement in HR+, HER+ disease. A year of treatment with the antibody-drug conjugate trastuzumab emtansine effectively prevents HER2-positive BC ... Eribulin is noninferior to trastuzumab and pertuzumab plus taxane in treating HER2-positive breast cancer. The HER2DX ERBB2 mRNA score was significantly associated with improved survival in patients with metastatic HER2+ BC. Using the HER2DX genomic tool is feasible in a real-world setting of patients with early-stage HER2-positive breast cancer. CNS radiotherapy with pyrotinib and capecitabine improves CNS progression in breast cancer patients with brain metastases. Will HER2CLIMB-02 study data impact the breast cancer landscape? In a recent study, published in JAMA Oncology, researchers evaluated whether the HER2DX assay could predict ...