Rob Dillard

DocwireNews

A new study suggests that patients with chronic obstructive pulmonary disease (COPD) should be treated with an inhaler combination containing long-acting muscarinic antagonists (LAMAs) and long-acting &beta;-agonists (LABAs) instead of inhalers containing inhaled corticosteroids (ICSs) and LABAs. The findings <a href="https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2804685">appeared</a> this week in JAMA Internal Medicine.&nbsp;COPD guidelines recommend LAMA-LABAs over ISC-LABAs; however, clinical trial data, as the researchers noted, &ldquo;have been conflicting and raised concerns of generalizability.&rdquo;In this study, Drs. William B. Feldman, Jerry Avorn, and Aaron S. Kesselheim, assessed 30,216 matched pairs of COPD patients who had a filled out a new prescription of ICS-LABAs or LAMA-LABAs between January 1, 2014, and December 31, 2019. The primary outcome was defined as the first moderate or severe COPD exacerbation, and the primary safety outcome was first pneumonia hospitalization.According to the results, LAMA-LABA use was associated with an 8% reduction in the rate of first moderate or severe COPD exacerbation compared with &nbsp;ICS-LABA use &nbsp;(HR=0.92; 95% CI, 0.89-0.96), as well as a 20% reduction in the rate of pneumonia hospitalization (HR=0.80; 95% CI, 0.75-0.86). The findings were robust across several subgroup analyses.&ldquo;In this cohort study, LAMA-LABA therapy was associated with improved clinical outcomes compared with ICS-LABA therapy, suggesting that LAMA-LABA therapy should be preferred for patients with COPD,&rdquo; the researchers concluded.

Jordana Jampel

Positive Preliminary Results From Phase 1 Trial of Dopaminergic Neuron Graft for Parkinson’s Disease

Dementia

Bradley Warady, MD

Joel M. Topf, MD, FACP

2025 Hume Award Winner Is Dedicated to Children’s Care

NKF Spring Clinical Meetings 2025

Distant Brain Metastases in Cutaneous Melanoma May Be Mitigated With Multiple Pathway Inhibitors

Melanoma

Latest News

What is the Right Inhaler Combination for COPD Patients?

Pulmonology

Study discerns the best inhaler combination to treat patients with COPD.

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe