Kerri Fitzgerald

DocwireNews

In this study published in&nbsp;Arthritis &amp; Rheumatology,&nbsp;researchers aimed to assess if&nbsp;tocilizumab (TCZ) monotherapy is noninferior to treatment with TCZ plus methotrexate (MTX) for maintaining clinical responses in patients with rheumatoid arthritis (RA),&nbsp;in whom low disease activity is achieved with TCZ plus MTX.&nbsp;In the study, out of the&nbsp;718 patients enrolled, 296 were randomized at week 24 to receive TCZ monotherapy (n = 147) or TCZ plus MTX (n = 147).&nbsp;Out of the patients who received an inadequate response to just MTX were given&nbsp;MTX plus TCZ 162 mg subcutaneously.&nbsp;Patients who achieved a Disease Activity Score in 28 joints using the erythrocyte sedimentation rate (DAS28&#8208;ESR) of &le;3.2&nbsp;at week&nbsp;24&nbsp;were randomized to either receive TCZ monotherapy or continue the TCZ plus MTX treatment.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
New RCT: Sustained Response Following Discontinuation of Methotrexate in Patients With Rheumatoid <a href="https://twitter.com/hashtag/Arthritis?src=hash&amp;ref_src=twsrc%5Etfw">#Arthritis</a> Treated With Subcutaneous Tocilizumab <a href="https://t.co/YOXSUKlZr3">https://t.co/YOXSUKlZr3</a> <a href="https://twitter.com/ACRheum?ref_src=twsrc%5Etfw">@ACRheum</a>
&mdash; Wiley Clinical Health (@WileyHealth) <a href="https://twitter.com/WileyHealth/status/988439919671595009?ref_src=twsrc%5Etfw">April 23, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
New2Trip: Sustained Response Following Discontinuation of Methotrexate in Patients w/ Rheumatoid Arthritis Treated &hellip; <a href="https://t.co/348yBNS6wK">https://t.co/348yBNS6wK</a>
&mdash; Trip Database (@tripdatabase) <a href="https://twitter.com/tripdatabase/status/1020948210729316352?ref_src=twsrc%5Etfw">July 22, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>&ldquo;Patients with RA receiving TCZ plus MTX who achieve low disease activity can discontinue MTX without significant worsening of disease activity during the 16 weeks following MTX discontinuation,&rdquo; the researchers concluded.&nbsp;Check out a recent article&nbsp;on the efficacy of&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/opioids-not-better-long-term-pain/">using opioids for joint and back pain</a>.&nbsp;&nbsp;SOURCE:&nbsp;<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40493">Arthritis &amp; Rheumatology&nbsp;</a>

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How Does Tocilizumab Monotherapy Compare to Tocilizumab Plus Methotrexate?

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In this study published in Arthritis &amp; Rheumatology, researchers aimed to assess if tocilizumab (TCZ) monotherapy is noninferior to treatment with TCZ plus methotrexate ...

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