Alexander Spira, MD, PhD, FACP, FASCO

DocwireNews

Alexander Spira, MD, PhD, FACP, FASCO, of Virginia Cancer Specialists, discussese the phase 2 SKIPPirr study results presented by Gilberto Lopes, MD, during the <a href="https://www.docwirenews.com/conference/iaslc-2024-world-conference-on-lung-cancer" target="_blank" rel="noopener">IASLC 2024 World Conference on Lung Cancer</a>.The global SKIPPirr study evaluated the use of prophylaxis in patients receiving oral lazertinib and intravenous amivantamab, as intravenous amivantamab has an infusion-related reaction incidence of around 67%, typically at the first infusion, according to investigators.&ldquo;The SKIPPirr study is a study looking at how we mitigate some of the infusion reactions from amivantamab,&rdquo; Dr. Spira said.The study enrolled patients with&nbsp;EGFR-mutated (Ex19del or L858R) advanced non-small cell lung cancer after disease progression on sequential osimertinib and platinum-based chemotherapy.&ldquo;This is a very straightforward study that looked at a couple of different ways to help mitigate those reactions,&rdquo; Dr. Spira said. &ldquo;One of which was giving dexamethasone premedication, one of which was giving methotrexate, and another was giving montelukast, the asthma and allergy drug.&rdquo;The study evaluated these strategies in 4 cohorts using Simon&rsquo;s 2-stage design strategy.&ldquo;I know this sounds very simple, but steroids actually helped,&rdquo; Dr. Spira said.Specifically, the study showed that prophylaxis with 8-mg oral dexamethasone &ldquo;resulted in a meaningful reduction&rdquo; in the infusion-related reaction incidence, according to the study authors.&ldquo;Giving patients dexamethasone at relatively modest doses can actually mitigate a lot of these infusion-related reactions,&rdquo; Dr. Spira said. &ldquo;This will be very helpful for our patients as they get this formulation going forward.&rdquo;

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The global SKIPPirr study evaluated the use of prophylaxis in patients receiving oral lazertinib and intravenous amivantamab.

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