Kaitlyn D’Onofrio

DocwireNews

A recent study found that&nbsp;tofacitinib&nbsp;effectively improved&nbsp;clinical, imaging, and biomarker end-points&nbsp;results in patients with rheumatoid arthritis (RA), and baseline multi-biomarker disease activity (MBDA) and power Doppler US (PDUS) scores may serve as predictors.&nbsp;Eligibility&nbsp;criteria included a baseline disease activity score&nbsp;(DAS28)&nbsp;of &gt; 3.2 and PDUS score &gt; 10. Patients&nbsp;(n = 25; mean age, 52 years; mean disease duration, 10.4 years, 88% were female; 40% were Caucasian)&nbsp;received&nbsp;a 5 mg oral dose of&nbsp;open-label&nbsp;tofacitinib&nbsp;twice a day and were evaluated at baseline, two weeks, and 12 weeks. Patients underwent musculoskeletal ultrasound&nbsp;(MSUS) at each visit&nbsp;for PDUS and gray scale ultrasound (GSUS)&nbsp;and were also evaluated for MBDA score, clinical disease activity index (CDAI), and DAS28.&nbsp;<a href="https://twitter.com/GoutBio/status/1062070917969235968">https://twitter.com/GoutBio/status/1062070917969235968</a>The mean DAS28 at baseline was 6.26, and mean CDAI was 40.&nbsp;At final follow-up, all patients showed significant improvement in PDUS, GSUS, MBDA score, DAS28, and CDAI. Researchers observed a significant correlation in 12-week changes in MBDA/MSUS with 12-week changes in CDAI/DAS28 in all except for GSUS with DAS28. After two weeks, changes in PDUS or GSUS indicated a significant 12-week change in DAS28 response. Initial PDUS, GSUS, and MBDA score indicated 12-week CDAI or DAS28 responses, except in GSUS with DAS28 response.&nbsp;The study&rsquo;s findings were presented at the annual American College of Rheumatology meeting.&nbsp;The researchers wrote in their abstract, &ldquo;This study showed that RA patients treated with tofacitinib for 12 weeks demonstrated significant responses with clinical, imaging, and biomarker end-points. In addition, baseline PDUS and MBDA score were predictive of the DAS28 and CDAI response at 12 weeks.&rdquo;&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/suboptimal-diabetes-screening/">Patients&nbsp;With&nbsp;Rheumatoid Arthritis Show Suboptimal Diabetes Screening Rates</a>&nbsp;<a href="https://proddocwire.wpengine.com/abstracts/herpes-zoster-tofacitinib-risk/">Herpes Zoster in Tofacitinib: Risk is Further Increased with Glucocorticoids but not Methotrexate</a>&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/palindromic-rheumatism-rheumatoid-arthritis/">Unique Imaging Sets Palindromic Rheumatism Apart from Rheumatoid Arthritis</a>&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/prevent-delay-rheumatoid-arthritis/">Therapeutic Interventions to Prevent and Delay Rheumatoid Arthritis Onset</a>&nbsp;Source:&nbsp;<a href="https://acrabstracts.org/abstract/baseline-power-doppler-and-multi-biomarker-disease-activity-score-predict-12-week-disease-activity-response-to-tofacitinib/">American College of Rheumatology&nbsp;</a>

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Study: Predictors of Tofacitinib Success in RA Patients

Rheumatology

A recent study found that tofacitinib effectively improved clinical, imaging, and biomarker end-points results in patients with rheumatoid arthritis (RA), and baseline ...

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