Kerri Fitzgerald

DocwireNews

Research published in Nature Medicine identified specific biomarkers that lead to better response in patients with chronic lymphocytic leukemia (CLL) who are receiving chimeric antigen receptor (CAR) T-cell therapy. Patients with CD8 and CD27 expression and the absence of CD45RO are more likely to achieve a complete or partial response. The study authors said this understanding may help with selecting patients who are mostly likely to benefit from CAR T-cell therapy.The study included 41 patients with advanced, high-risk CLL who were heavily pretreated and received at least one dose of CD19-directed CAR T cells. Patients with a sustained remission had an elevated frequency of CD27+CD45RO&ndash; CD8+ T cells before CAR T-cell generation.Source: <a href="https://www.nature.com/articles/s41591-018-0010-1.epdf?referrer_access_token=DYFFzvZ5jrvfTAwESx5QftRgN0jAjWel9jnR3ZoTv0MFc3JuQJaU1V59sbANgZAMUSvLmMAZN9VH5TiL7n54jKJRwQ28IShp_89G_cbwOR9PfUer657fpHhP9Dr-x9NufW9trbRR4Nylz-l0eB7JuvLklDxoP3g_uB40CGpfNxbEGKY33zKkeIMnxMCZK8QY&amp;tracking_referrer=www.medscape.com">Nature Medicine</a>

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Study Identifies Biomarker That Signals Better Response to CAR T-Cell Therapy

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Research published in Nature Medicine identified specific biomarkers that lead to better response in patients with chronic lymphocytic leukemia (CLL) who are receiving ...

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