Kaitlyn D’Onofrio

DocwireNews

A new study evaluated the correlation between elevated levels of anti-citrullinated protein antibodies (ACPA) prior to a <a href="https://www.docwirenews.com/abstracts/rheumatology-abstracts/use-of-rheumatologic-testing-in-patients-who-eventually-receive-a-diagnosis-of-rheumatoid-arthritis/">diagnosis</a> of <a href="https://www.docwirenews.com/abstracts/rheumatology-abstracts/assessment-of-aortic-stiffness-in-patients-with-rheumatoid-arthritis-using-pulse-wave-velocity-an-update-meta-analysis/">rheumatoid arthritis</a> (RA) and chronic obstructive pulmonary disease (COPD) and/or asthma.&ldquo;Prior studies have demonstrated a relationship between RA and subsequent COPD risk,&rdquo; the researchers wrote. &ldquo;Several case-control studies and retrospective cohorts were limited by the inability to investigate serologic status or account for smoking, a strong risk factor for both COPD and RA. Some studies found that this association is more pronounced in seropositive RA and independent of smoking.&rdquo;They further noted that, &ldquo;Prior studies have also investigated the association between RA and asthma, with some showing that RA increased asthma risk, but these studies lacked data on ACPA status or smoking. A previous study suggested that airway abnormalities are more common in patients with pre-RA seropositivity than controls but was cross-sectional and did not study clinically diagnosed obstructive lung diseases.&rdquo;<h2>ACPA Levels Indicate COPD and Asthma Risk</h2>The study, published in <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.24140?referrer_access_token=4_aO2FIDZOiynZoxqay2MU4keas67K9QMdWULTWMo8NGVhkYF2iip1IKmST6FGwAB2qTtKPzHNsJb9vd05q3OuS0TTD7wypV9HuDsbInmbqcmp63phUz6XlaNzrw_-hFIKigi3of-3VkvYhbJgxVuQ%3D%3D">Arthritis Care &amp; Research</a>, included data from the Nurses&rsquo; Health Studies on women who had donated blood. Women who reported incident RA following blood draw were matched 1:3 to control patients based on age, cohort, year, and menopausal factors. The researchers defined pre-RA ACPA+ as &ldquo;&gt;99th percentile of control distribution by a research assay or by CCP2 in a subset.&rdquo; Questionnaires were used to determine which patients went on to develop COPD and asthma after blood draw.Final analysis included 283 pre-RA women and 842 control patients. For women who were eventually diagnosed with RA, blood draw was performed a mean 9.7 (SD=5.8) years prior to diagnosis. About one in five women (n=59, 20.8%) were pre-RA ACPA+. Over 21,489 person-years of follow-up, 107 cases of incident COPD and 105 incident cases of asthma were reported. When adjusting for covariates, including smoking pack-years, women with pre-RA ACPA+ were significantly more likely to develop COPD (hazard ratio [HR]=3.04; 95% confidence interval [CI], 1.33&ndash;7.00). Pre-RA ACPA+ was also correlated with a greater risk for asthma (HR=1.74; multivariable 95% CI, 0.72&ndash;4.24), as was pre-RA ACPA- (HR=1.65; 95% CI, 1.11&ndash;2.46).&ldquo;Women with elevated ACPA before RA diagnosis had increased risk for developing COPD compared to controls. Women who later developed RA were more likely to develop asthma, regardless of pre-RA ACPA status,&rdquo; summarized the authors.

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Some Women With RA Are More Likely to Develop COPD or Asthma—This Antibody Could Be a Predictor

Rheumatoid Arthritis

A new study evaluated the correlation between elevated levels of anti-citrullinated protein antibodies (ACPA) prior to a diagnosis of rheumatoid arthritis (RA) and chronic ...

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