Victoria Socha

DocwireNews

Albuminuria, hypertension, declining kidney function, and an increase in cardiovascular risk are all hallmarks of diabetic kidney disease (DKD). Those clinical features are also related to&nbsp; premature mortality associated with type 1 diabetes.In a recent issue of Frontiers in Nephrology [doi.org/10.3389/fneph.2023.1282818], Fanny Jansson Sigfrids, PhD, and colleagues provided an overview of progression and regression of kidney disease in patients with type 1 diabetes.Early studies of albuminuria related to type 1 diabetes date back to the 1980s. Those studies demonstrated that 35% to 45% pf patients with type 1 diabetes developed proteinuria (equivalent of severe albuminuria), with the diabetes duration-specific incidence rate pattern portraying one or two peaks. In addition, moderate albuminuria was found to progress to overt kidney disease within a short span of time in nearly all patients.Following the early studies, there have been more recent trials updating incidence rates. Those recent trial results suggest that moderate&mdash;rather than severe&mdash; albuminuria develops in one-third of patients with type 1 diabetes. Up to 40% of patients progress to more advanced stages over time.Regression of albuminuria occurs in up to 60% of patients; however, the rate of relapse to a more advanced disease stage is high. There are few and conflicting data on whether albuminuria regression translates into a decline in cardiovascualr disease and premature mortality risk. Another finding is that while the incidence of severe albuminuria has fallen since the 1930s, the decline may have reached a plateau following the 1980s.The authors added, &ldquo;This stagnation may be due to the lack of kidney-protective medicines since the early 1980s, as the recent breakthroughs in type 2 diabetes have not been applicable to type 1 diabetes, Therefore, novel treatment strategies are a high priority within this patient population.&rdquo;Source: <a href="https://www.frontiersin.org/articles/10.3389/fneph.2023.1282818/full" target="_blank" rel="noopener">Frontiers in Nephrology</a>

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Progression and Regression of Albuminuria in Type 1 Diabetes

Part of NephTimes Diseases and Conditions

Diabetes and Hypertension

Researchers present an overview of progression and regression of kidney disease in patients with type 1 diabetes.

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