DocWire News Editors

DocwireNews

According to a study in&nbsp;<a href="https://ard.bmj.com/content/77/8/1099">Annals of the Rheumatic Diseases</a>,&nbsp;there have been recent advances in knowledge of the pathogenesis of rheumatoid arthritis (RA)&nbsp;that&nbsp;has led to promoting very early intervention.&nbsp;By using a&nbsp;systematic literature review (SLR) and meta-analysis (MA), researchers aimed to&nbsp;assess the efficacy of therapeutic interventions in preventing or delaying RA onset.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Pick them up early people&hellip; <a href="https://t.co/m6D7RuGCyS">https://t.co/m6D7RuGCyS</a>
&mdash; The Rheumatology Physio (@physiojack) <a href="https://twitter.com/physiojack/status/1009825565447278592?ref_src=twsrc%5Etfw">June 21, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
New2Trip: Ability of disease-modifying antirheumatic drugs to prevent or delay rheumatoid arthritis onset: sys&hellip; <a href="https://t.co/VOnTAG1SEo">https://t.co/VOnTAG1SEo</a>
&mdash; Trip Primary Care (@TripPrimaryCare) <a href="https://twitter.com/TripPrimaryCare/status/1019563863107428352?ref_src=twsrc%5Etfw">July 18, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>The study used&nbsp;randomized controlled trials&nbsp;from&nbsp;PubMed, EMBASE,&nbsp;and Cochrane databases for English articles published from 2006 to 2016.&nbsp;Patients in these articles used&nbsp;disease-modifying antirheumatic drugs or glucocorticoids used in patients. These patients&nbsp;presented&nbsp;genetic and/or environmental risk factors for RA and/or systemic autoimmunity associated with RA, and/or symptoms without clinical arthritis and/or unclassified arthritis and in patients with RA.&nbsp;RevMan&nbsp;with the Mantel-Haenszel&nbsp;method&nbsp;was used to perform the&nbsp;MA.&nbsp;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Ability of disease-modifying antirheumatic drugs to prevent or delay rheumatoid arthritis onset: a systematic literature review and meta-analysis <a href="https://t.co/M1zrsNX5TF">https://t.co/M1zrsNX5TF</a>
&mdash; Dr Eugene Lim (@ElimRheumCtr) <a href="https://twitter.com/ElimRheumCtr/status/1007517422964891648?ref_src=twsrc%5Etfw">June 15, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Ten reports of trials were selected out of the 595 abstracts originally screened. The occurrence of RA was available for nine studies; these studies assessed methylprednisolone, methotrexate, a tumor necrosis factor blocker, abatacept, or rituximab. In the group of people at risk of RA, the MA of the two available studies did not show significant reduction in RA occurrence at week 52 or more (pooled OR 0.74, 95%&thinsp;CI 0.37 to 1.49). The MA of the seven available studies revealed significant risk reduction with OR 0.73(95% CI 0.56 to 0.97) for people with undifferentiated arthritis.&ldquo;This MA demonstrates that early therapeutic intervention may significantly reduce the risk of rheumatoid arthritis onset in this very first phase of the disease,&rdquo; the researchers concluded.Check out a recent article on <a href="https://proddocwire.wpengine.com/docwire-pick/where-does-cannabinoids-stand-for-rheumatic-diseases/">cannabis and its use for rheumatic diseases</a>.SOURCE: <a href="https://ard.bmj.com/content/77/8/1099">Annals of the Rheumatic Diseases </a>

Areef Ishani, MD

Joel M. Topf, MD, FACP

Kidney Stones With Chlorthalidone Versus Hydrochlorothiazide

NKF Spring Clinical Meetings 2025

MarkAlain Déry, DO

Eric Griggs, MD

Measles in America: An Ongoing Problem

Infectious Disease

Roger Rodby, MD

Seldin Award Winner Advocates Online Education

Latest News

Therapeutic Interventions to Prevent and Delay Rheumatoid Arthritis Onset

Rheumatoid Arthritis

According to a study in Annals of the Rheumatic Diseases, there have been recent advances in knowledge of the pathogenesis of rheumatoid arthritis (RA) that has led to ...