DocWire News Editors

DocwireNews

There is an urgent need for more studies of the value of screening programs in individuals at high risk of having myeloproliferative neoplasms (MPNs), according to a study presented at the 12th International Congress on Myeloproliferative NeoplasmsIn this study, researchers enrolled 19,958 participants from the Danish General Suburban Population study, which was conducted from 2010-2013 and included DNA, blood tests, and questionnaires screened for JAK2V617F and CALR by a multiple droplet digital assay. They compared basic characteristics and blood tests between the mutation positive and the non-mutated population.&nbsp;Following analysis, the findings of the study showed that 3.5% of participants were mutation positive and of those, 2.5% had MPN at baseline. Also, 613 participants were JAK2V617F positive and 32 participants were CALR positive. The researchers observed that risk factors for the mutations included advanced age, smoking, and alcohol. The results also showed that JAK2V617F positives, with and without MPN, presented increased odds for prevalent venous thromboembolism. The odds ratio (OR) for a diagnosis of MPN per percentage allele burden was 1.14 (95% CI, 1.09 to 1.18). Overall, mutation positives showed higher blood cell counts juxtaposed to non-mutated with 40% of mutation positives without MPN presenting elevated blood cell counts.&ldquo;We present a novel population prevalence of the CALR and JAK2V617F mutations, being 3-30 times higher compared to less sensitive methods,&rdquo; the research authors wrote. &ldquo;Mutation positive non-MPNs have elevated blood cell counts which raise concerns of underdiagnosis of MPN in the population, in Denmark an estimate of 10,000 citizens with undiagnosed MPNs and accordingly 550,000 undiagnosed MPNs in US having an increased risk of life-threatening or life-invalidating blood clots in the brain, heart, lungs and elsewhere &ndash; an adding to this also carrying a 40 % increased risk of second cancer.&rdquo;Skov V, et al. Prevalence and Phenotypes of JAK2V617F and Calreticulin Mutations in a Danish General Population. Presented at the 12th International Congress on Myeloproliferative Neoplasms; October 24-25, 2019; New York, NY.

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

Prevalence and Phenotypes of JAK2V617F and Calreticulin Mutations in a Danish General Population

MPN Conference Coverage 2019

There is an urgent need for more studies of the value of screening programs in individuals at high risk of having myeloproliferative neoplasms (MPNs), according to a study ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe