Victoria Socha

DocwireNews

Worldwide, the most common cause of end-stage kidney disease (ESKD) is diabetic kidney disease (DKD). Results of studies have suggested that urinary podocyte stress biomarker (podocin:nephrin mRNA ratio), is a surrogate marker of podocyte injury in patients with nondiabetic kidney disease.&nbsp;Researchers, led by Lingfeng Zeng, PhD, conducted a study of 118 patients with biopsy-proven DKD and 13 nondiabetic controls. Participants&rsquo; urinary mRNA levels of nephrin, podocin, and aquaporin-2 (AQP2) were quantified. The outcome of interest was a renal event at 12 months, defined as death, the need for dialysis, or a 40% reduction in glomerular filtration rate.&nbsp;In the group with DKD, urinary podocin:nephrin mRNA ratio was significantly higher than in the control group (P=.0019). There were no differences between the two groups in urinary nephrin:AQP2 or podicin:AQP2 mRNA ratios.&nbsp;In the DKD group, there was a correlation between urinary podocin:nephrin mRNA ratio and the severity of tubulointerstitial fibrosis (r=0.254; P=.006). Urinary podocin:nephrin mRNA ratio was also associated with renal event-free survival (EFS) at 12 months (unadjusted hazard ratio [HR], 1.523; 95% CI, 1.157-2.006; P=.003). Following adjustment for clinical and pathological factors, there was a trend for urinary podocin:nephrin mRNA ratio as a predictor of renal EFS; however, the result did not reach statistical significance (adjusted HR, 1.327; 95% CI, 0.980-1.797; P=.067).&nbsp;In conclusion, the authors said, &ldquo;Urinary podocin:nephrin mRNA ratio has a marginal prognostic value in biopsy-proven DKD. Further validation is required for DKD patients without kidney biopsy.&rdquo;&nbsp;Source: <a href="https://www.doi.org/10.1186/s12882-024-03471-8" target="_blank" rel="noopener">BMC Nephrology</a>&nbsp;

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Predicting Renal Outcomes in Patients With DKD

Part of NephTimes Diseases and Conditions

Diabetes and Hypertension

Researchers studied whether podocin:nephrin mRNA ratio could be a surrogate marker of podocyte injury in patients with diabetic kidney disease (DKD).

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