Rob Dillard

DocwireNews

<p>Diet quality evaluated during midlife showed no significant association with any subsequent risk of developing dementia, according to a UK study <a href="https://jamanetwork.com/journals/jama/fullarticle/2727449?guestAccessKey=1abbcb7e-2eec-43b3-a335-bc80158b0a4a&amp;utm_source=JAMA_Network&amp;utm_medium=referral&amp;utm_campaign=ftm_links&amp;utm_content=tfl&amp;utm_term=031219">published</a> in <em>JAMA.</em><p>In this population-based cohort study, known as Whitehall II and established in 1985-1988, researchers assessed diet quality during midlife by querying 8,225 participants (mean age, 50, 69.1% male) without dementia using the Alternate Health Eating Index (AHEI, score range, 0-110). The AHEI score consists of 11 components: six components for which the highest intake is seen to be ideal (vegetables, fruits, whole grains, nuts and legumes, long-chain omega-3 fatty acids, and polyunsaturated fatty acids [excluding long-chain omega-3 polyunsaturated fatty acids]); and four components for which avoidance or the lowest intake is seen to be optimal (sugar-sweetened drinks and fruit juice, red and processed meat, trans fat, and sodium). Dietary intake was appraised during 1991-1993, 1997-1999, and 2002-2004 using a machine-readable food frequency questionnaire (FFQ). The primary outcome was incident dementia and the secondary outcome was cognitive decline between 1997-1999 and 2015-2016.</p><h2><strong>No Diet/Dementia Correlation Observed</strong></h2><p>Among all participants, a total of 344 cases of incident dementia were recorded during a median follow-up of 24.8 years. Researchers observed no difference in the incidence rate for dementia in the tertiles of AHEI exposure during 1991-1993, 1997-1999 (average follow-up, 19.1 years), or 2002-2004 (average follow-up, 13.5 years). Juxtaposed with an incidence rate for dementia of 1.76 (95% CI:1.47-2.12) per 1,000 person-years in the lowest tertile of AHEI in 1991-1993, the absolute rate difference for the intermediate tertile was 0.03 (95% CI:&minus;0.43 to 0.49) per 1000 person-years and for the best tertile was 0.04 (95% CI:&minus;0.42 to 0.51) per 1000 person-years. Compared with the worst AHEI tertile in 1997-1999 (incidence rate for dementia, 2.06 [95% CI:1.62 to 2.61] per 1000 person-years), the absolute rate difference for the intermediate AHEI tertile was 0.14 (95% CI:&minus;0.58 to 0.86) per 1000 person-years and for the best AHEI tertile was 0.14 (95% CI:&minus;0.58 to 0.85) per 1000 person-years.</p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">Association of Midlife Diet With Subsequent Risk for Dementia:  In this long-term prospective cohort study, diet quality assessed during midlife was not significantly associated with subsequent risk for dementia. <a href="https://t.co/jtGXcatgqn">https://t.co/jtGXcatgqn</a></p>
<p>&mdash; Dr Rigoberto Marcano: M&eacute;dico internista (@rigotordoc) <a href="https://twitter.com/rigotordoc/status/1105654215995768832?ref_src=twsrc%5Etfw">March 13, 2019</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><p>Moreover, compared with the lowest AHEI tertile in 2002-2004 (incidence rate for dementia, 3.12 [95% CI:2.49 to 3.92] per 1000 person-years, the absolute rate difference for the intermediate AHEI tertile was &minus;0.61 (95% CI:&minus;1.56 to 0.33) per 1000 person-years and for the best AHEI tertile was &minus;0.73 (95% CI: &minus;1.67 to 0.22) per 1000 person-years.</p><p>Furthermore, in the multivariable analysis, the adjusted hazard ratios (HRs) for dementia per 1-SD (10-point). AHEI increment were not significant as assessed in 1991-1993 (adjusted HR=0.97 [95% CI:0.87 to 1.08]), in 1997-1999 (adjusted HR=0.97 [95% CI:0.83 to 1.12]), or in 2002-2004 (adjusted HR=0.87 [95% CI:0.75 to 1.00]).</p><h2><strong>Diet and Cognitive Outcomes Connection Remains Unclear</strong></h2><p>&ldquo;The lack of a significant association between early midlife diet and cognitive outcomes is unlikely to be due to poor measures of diet quality because diet was associated with mortality in the present study,&rdquo; stated the authors of this study. &ldquo;Whether a healthy diet plays a role in shaping cognitive outcomes in combination with other healthy behaviors or in subgroups at increased risk for dementia remains unclear.&rdquo;</p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">In this long-term prospective cohort study, <a href="https://twitter.com/hashtag/diet?src=hash&amp;ref_src=twsrc%5Etfw">#diet</a> quality assessed during midlife was not significantly associated with subsequent risk for <a href="https://twitter.com/hashtag/dementia?src=hash&amp;ref_src=twsrc%5Etfw">#dementia</a>.   :- Association of Midlife Diet With Subsequent Risk for Dementia <a href="https://t.co/05qdMbD4DS">https://t.co/05qdMbD4DS</a></p>
<p>&mdash; Jagadish K Chhetri, MD,PhD (@JagadishChhetri) <a href="https://twitter.com/JagadishChhetri/status/1105657295810240513?ref_src=twsrc%5Etfw">March 13, 2019</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><p>https://twitter.com/JagadishChhetri/status/1105657295810240513https://twitter.com/adamcifu/status/1106379364923523074</p></p>


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Midlife Diet Shows No Association with Subsequent Risk for Dementia

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Diet quality evaluated during midlife showed no significant association with any subsequent risk of developing dementia, according to a UK study published in JAMA. ...

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