Patrick Daly

DocwireNews

According to Masahiro Katsurada and colleagues, few studies have evaluated the combination of sedatives and opioids in patients undergoing bronchoscopy. They conducted a randomized trial on midazolam with or without pethidine in patients undergoing bronchoscopy and found that &ldquo;the combination uses of midazolam and pethidine for sedation resulted in significant improvements in the pain, blood pressure, additional use of midazolam, and safety during bronchoscopy among patients,&rdquo; according to their article in&nbsp;BMC Cancer.The study included 100 patients who were scheduled to undergo bronchoscopy biopsy. After the procedure, the patients completed a questionnaire. The primary endpoint of the study was the &ldquo;patients&rsquo; acceptance of re-examination assessed by visual analogue scale.&rdquo; Additional measures in the study included pain, vital signs, midazolam use, xylocaine use, and adverse events.&nbsp;The final analysis included 47 patients in the midazolam and pethidine combination group and 49 patients in the midazolam only group.<h2>Bronchoscopy Sedation Results</h2>In the article, the researchers reported that &ldquo;the primary outcome was a good trend in the combination group, but not significantly different (3.82&thinsp;&plusmn;&thinsp;2.3 in combination group versus 4.17&thinsp;&plusmn;&thinsp;2.75 in midazolam alone; p&thinsp;=&thinsp;0.400). Notably, the visual analog scores for pain levels during bronchoscopy were significantly lower in the combination group compared to the midazolam group (p = 0.022), and the combination group&rsquo;s sedation level was &ldquo;significantly deeper&rdquo; (p = 0.031). In addition, both additional midazolam use, maximal systolic blood pressure during testing, and adverse events were significantly lower for patients in the combination group.In summary, the investigators proposed that &ldquo;the combination of midazolam and pethidine attenuated pain and showed significant improvements in objective indicators such as vital signs and adverse events&rdquo; in patients undergoing sedation for bronchoscopy.&rdquo;Browse more <a href="https://www.docwirenews.com/latest-hematology-oncology-news-2/">hematology and oncology expert articles and videos</a>

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According to Masahiro Katsurada and colleagues, few studies have evaluated the combination of sedatives and opioids in patients undergoing bronchoscopy. They conducted a ...

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