Patrick Daly

DocwireNews

Researchers, led by Lisa Jakobsen, evaluated the relation between different prothrombotic genotypes and a high mean platelet volume (MPV) to determine if there was a &ldquo;joint effect&rdquo; on risk for <a href="https://www.cdc.gov/ncbddd/dvt/facts.html">venous thromboembolism</a> (VTE). The authors&rsquo; article, published in Thrombosis and Haemostasis, reported that the combined effects of high MPV and prothrombotic genotypes had an additive impact on risk for VTE.&nbsp;According to Jakobsen, this finding suggested that &ldquo;there is no biological interaction between these risk factors in the pathogenesis of VTE.&rdquo;The study enrolled 653 incident cases of VTE and a cohort of 1,774 subjects from the Troms&oslash; Study (1994&ndash;2012). Researchers designated MPV strata of &lt;8.5, 8.5&ndash;9.5, and &ge;9.5fL, and genotyped five single nucleotide polymorphisms (SNPs)&mdash;rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2036914 (F11), and rs2066865 (FGG). Models were adjusted for age, sex, body mass index, and platelet count.<h2>Mean Platelet Volume and SNP Profile for VTE Risk</h2>Based on their observations, the authors concluded that high MPV combined with presence of risk alleles&mdash;either in individual SNPs or in various combinations&mdash;did result in an additive effect of VTE risk. Reportedly, subjects with high MPV (&ge;9.5fL) and &ge;4 risk alleles had hazard ratios (HRs) of 2.80 (95% confidence interval [CI], 1.77&ndash;4.43) for overall VTE and 4.60 (95% CI, 2.20&ndash;9.60) for unprovoked events, respectively, compared to cases with MPV &lt;8.5fL and zero or one risk alleles.Given that Jakobsen and colleagues did not find a &ldquo;supra-additive&rdquo; impact on VTE risk estimates, they ultimately concluded that high MPV and prothrombotic genotype profiles are both risk factors for VTE, but there does not appear to be a biological interaction.Visit the <a href="https://www.docwirenews.com/venous-thromboembolism-knowledge-hub/">Venous Thromboembolism Knowledge Hub</a> for Related Research

Jordana Jampel

Positive Preliminary Results From Phase 1 Trial of Dopaminergic Neuron Graft for Parkinson’s Disease

Dementia

Bradley Warady, MD

Joel M. Topf, MD, FACP

2025 Hume Award Winner Is Dedicated to Children’s Care

NKF Spring Clinical Meetings 2025

Distant Brain Metastases in Cutaneous Melanoma May Be Mitigated With Multiple Pathway Inhibitors

Melanoma

Latest News

Mean Platelet Volume and Thrombotic Genotypes Predict Venous Thromboembolism Risk

Researchers, led by Lisa Jakobsen, evaluated the relation between different prothrombotic genotypes and a high mean platelet volume (MPV) to determine if there was a "joint ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe