Andrew Moreno

DocwireNews

A database study of patients with myelodysplastic syndrome (MDS) provides a picture of patients&rsquo; quality of life by change or persistence in transfusion dependency status. The study was recently published in Leukemia &amp; Lymphoma.&ldquo;Achieving transfusion independence in MDS correlates with improved quality of life, whereas reverting to transfusion dependence more significantly worsens overall quality of life and function scores,&rdquo; wrote lead author for the study Rena Buckstein, MD, FRCPC, of Sunnybrook Health Sciences Centre in Toronto, Canada.The authors&rsquo; investigation incorporated the data of 1,120 patients from a Canadian national MDS registry. They organized the patients into four categories by transfusion status of having converted from dependence to independence, from independence to dependence, maintained dependence, or maintained independence.The authors&rsquo; analysis found that overall survival among the four groups was superior for patients who had maintained transfusion independence, intermediate for patients who had converted from dependence to independence or vice versa, and worse in patients who had maintained dependence.The authors also specifically analyzed data from 656 patients who had undergone treatment. They found that those who converted from transfusion dependence to independence saw improved global quality of life scores, as well as an improvement trend in social function and physical scores. Patients who converted from independence to dependence had declines in quality of life, social function, physical scores, and especially reported fatigue.Treated patients who remained transfusion dependent reported worsening fatigue. Those who remained independent experienced comparatively mild declines in several quality of life measures.ReferenceWan BA, Alibhai SMH, Chodirker L, et al. Improvement in quality of life in MDS patients who become transfusion independent after treatment. Leuk Lymphoma. 2024. doi:10.1080/10428194.2024.2422844

Jordana Jampel

Mechanism of Positive Association Between Parkinson’s Disease and Melanoma Revealed in New Research

Melanoma

Hatem Soliman, MD

Using Dendritic Cell Vaccines to Boost Neoadjuvant Therapy in HER2+ Breast Cancer

HER2 Breast Cancer

Kathleen Liu, MD

Joel M. Topf, MD, FACP

AKI Approaches and ASN Kidney Health Guidance

NKF Spring Clinical Meetings 2025

Latest News

MDS Database Study Looks at Patient Quality of Life by Transfusion Dependency Status

The investigators compiled patients' quality of life, social function, and physical scores, and assessed overall survival.

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe