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Researchers, led by Aurore Bonnet-Lebrun, theorized that quantifying bone parameters in children with X-linked hypophosphatemia (XLH) rickets would help document and monitor the lower limb and pelvic deformities caused by XLH. Their quantitative analysis, published in Orthopaedics &amp; Traumatology: Surgery &amp; Research, found that deformities in XLH are primarily&mdash;though not exclusively&mdash;in the femoral shaft, and are highly variable from one patient to another.The study enrolled 35 growing children with XLH for assessment, and a control group of 40 age-matched patients to define reference values for the parameters. Three-dimensional biplanar radiographs of patients&rsquo; legs and pelvis were analyzed for 16 geometric parameters.In the leg parameters, significant differences were observed between patients with XLH and control patients for the neck-shaft angle, femur/tibia length ratio, and hip-knee shaft (HKS; p &lt;0.05). Additionally, genu varum leg (n = 23/70) and genu valgum leg (n = 25/70) subgroups had significant differences in femoral mechanical angle and HKS. The investigators also observed a strong correlation between the femoral mechanical angle and femorotibial angle (r2 = 0.73), as well as between the femoral mechanical angle and HKS (r2 = 0.69). Lastly, the sacral slope and acetabular anteversion were significantly different than the reference parameters.The quantitative analysis led the study&rsquo;s authors to draw the aforementioned conclusions, and further theorize that &ldquo;some of these radiological parameters may be useful for the diagnosis and monitoring of XLH patients.&rdquo;

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Lower Limb and Pelvic Deformities in Pediatric Patients with X-Linked Hypophosphatemic Rickets

Nephrology Times

Researchers, led by Aurore Bonnet-Lebrun, theorized that quantifying bone parameters in children with X-linked hypophosphatemia (XLH) rickets would help document and monitor ...

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