Patrick Daly

DocwireNews

Liquid biopsy (LB) serves as a robust tool for identifying genetic alterations in patients with myeloid neoplasms, according to a study presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting.In this retrospective study, Douglas A. Mata and colleagues collated LB samples from 48,459 unique samples submitted for comprehensive genomic profiling (CGP). The population of interest had histiocytic neoplasms (HNs), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), or acute myeloid leukemia (AML). In the full study group, 83 patients had myeloid neoplasms: 34 HN, 23 MDS, 15 MPN, and 11 AML.The results showed that reportable genetic alterations were detected in almost 63% of patients. Specifically, the researchers observed that LB identified pathogenic alterations at a rate of 31% in BRAF, 12.5% in NF1, 6.3% in MAP2K1, and 6.3% in NRAS, and detected VAFs as low as 0.21%, 0.13%, 0.11%, and 4.0%, respectively.&ldquo;LB identified clinically relevant genomic alterations in myeloid neoplasia, offering a powerful tool that may be used pre- or post-treatment when CGP of the buffy coat, marrow, or tissue is infeasible,&rdquo; the researchers concluded. &ldquo;Given its low limit of detection, LB can also identify low-level emerging or persistent subclones, which may facilitate monitoring and minimal residual disease testing.&rdquo;

Connie Rhee, MD

Joel M. Topf, MD, FACP

CKD Management and Cognition

NKF Spring Clinical Meetings 2025

Bradley Marder, MD

Gout Studies: Transplant Waitlisting and Bone Erosion

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Latest News

Liquid Biopsy Effective at Finding Gene Alterations in Patients With Myeloid Neoplasms

ASCO 2022

Liquid biopsy (LB) serves as a robust tool for identifying genetic alterations in patients with myeloid neoplasms, according to a study presented at the 2022 American Society ...

Liquid Biopsy Effective at Finding Gene Alterations in Patients with Myeloid Neoplasms

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe