Charlotte Robinson

DocwireNews

Information on the association between chronic tonsillitis and the onset of IgA nephropathy (IgAN) is lacking, so Takashin Nakayama, MD, and others studied the potential relationship between chronic tonsillitis and a subsequent risk of developing IgAN. They reported the findings of their observational cohort study in the American Journal of Kidney Diseases.The researchers identified 4,311,393 patients with no history of IgAN between January 2005 and May 2022 using the JMDC Claims Database, a nationwide Japanese epidemiological database, representing claims to more than 60 health insurers. Criteria for selection included individuals who had a health checkup more than 12 months after insurance enrollment (12-month lookback period).Median age of the cohort was 44 years (interquartile range [IQR], 36-53); 57.9% were male. The researchers identified cases of comorbid chronic tonsillitis among the cohort prior to the initial checkup based on diagnosis codes. In total, 12,842 (0.3%) participants had comorbid chronic tonsillitis.During a follow-up period of 1089 days (IQR, 532-1797), 2653 cases of IgAN occurred. Cumulative incidence curve found that the cumulative incidence of IgAN was higher in patients with chronic tonsillitis versus patients without tonsillitis. A multivariable, cause-specific analysis also found that patients with chronic tonsillitis had an increased risk of developing IgAN (hazard ratio, 2.72; 95% CI, 1.79-4.14).The authors acknowledged limitations of their study, including potential residual confounders and lack of consideration for ethnic distinctions. Nonetheless, their findings point to a relationship between chronic tonsillitis and an elevated risk of developing IgAN in a general Japanese population.&ldquo;In summary,&rdquo; they wrote, &ldquo;after analyzing a nationwide epidemiological database, we identified an increased risk of IgAN incidence associated with chronic tonsillitis. This [finding] underscores the clinical significance of collaborative efforts between general physicians (otorhinolaryngologists) and nephrologists in the management of individuals with chronic tonsillitis.&rdquo;Source: <a href="https://doi.org/10.1053/j.ajkd.2024.04.015" target="_blank" rel="noopener">American Journal of Kidney Diseases</a>

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Is There an Association Between Chronic Tonsillitis and IgAN?

IgA Nephropathy

Information on a possible association between chronic tonsillitis and IgA nephropathy (IgAN) has been lacking.

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