Kerri Fitzgerald

DocwireNews

A study published in Blood observed an increased risk of arterial thromboembolic events&mdash;including myocardial infarction and stroke&mdash;5 months prior to a cancer diagnosis.Researchers assessed the Surveillance Epidemiology and End Results&ndash;Medicare dataset to identify 374,331 patients with cancer who were 67 years or older with a new primary diagnosis of breast, lung, prostate, colorectal, bladder, uterine, pancreatic, gastric cancer, or non-Hodgkin lymphoma between 2005 and 2013.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Patients with cancer are not only at higher risk of venous events: "Arterial thromboembolic events preceding the diagnosis of cancer in older persons" <a href="https://t.co/IBWVYOcRcK">https://t.co/IBWVYOcRcK</a> <a href="https://t.co/SZQNNV3JhZ">https://t.co/SZQNNV3JhZ</a>
&mdash; Scott Tagawa (@DrScottTagawa) <a href="https://twitter.com/DrScottTagawa/status/1076239836170858496?ref_src=twsrc%5Etfw">December 21, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Patients were then matched to individual controls without cancer based on year of birth, sex, race, and the presence of some other comorbidities, for a final participant total of 748,662.Researchers used the Mantel-Haenszel estimator to compare risks of arterial thromboembolic events between the cancer and non-cancer groups during 30-day periods in the 360 days before date of cancer diagnosis.From 360 to 151 days before cancer diagnosis, the 30-day interval risks of arterial thromboembolic events were similar between patients with cancer and matched controls. However, from 150 to 1 day before a cancer diagnosis, the interval 30-day risks of arterial thromboembolic events were higher in patients with cancer, and this progressively increased as the cancer diagnosis date approached, peaking during the 30-days immediately before cancer diagnosis.<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
The risk of heart attack or stroke is increased by 70% in the 12 months and 500% in the 1 month before a cancer dx, highest in adults with lung and colorectal cancers and those with stage 3 or 4 disease. OMG! <a href="https://t.co/O0TLNEVg6P">https://t.co/O0TLNEVg6P</a>
&mdash; Craig Hofmeister (@EagleMyeloma) <a href="https://twitter.com/EagleMyeloma/status/1076137938726121475?ref_src=twsrc%5Etfw">December 21, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>At 30 days prior to diagnosis, the risk of developing an arterial thromboembolic event was more than 5.5-fold higher in the cancer cohort compared with the control group (P&lt;0.001). Specifically, 2,313 (0.62%) patients with cancer were diagnosed with an arterial thromboembolic event compared with 413 (0.11%) controls (odds ratio = 5.63; 95% CI, 5.07-6.25).During the 360 days prior to a cancer diagnosis, the risk of developing an arterial thromboembolic event was 69% higher among those who were later diagnosed with cancer compared with controls (1.75% vs 1.05%; P&lt;0.001).The highest risk of an arterial thromboembolic event in the 360 days preceding their diagnosis occurred in patients diagnosed with lung cancer, followed by colorectal cancer.<a href="https://proddocwire.wpengine.com/docwire-pick/vitamin-d-omega-3-cancer-heart-disease/">A new study says certain supplements do not prevent cancer or heart disease.</a><a href="https://proddocwire.wpengine.com/docwire-pick/night-shift-work-associated-with-risk-of-cancer-metabolic-disorders/">Night shift work is associated with a risk of cancer and metabolic disorders.</a>Source: <a href="http://www.bloodjournal.org/content/early/2018/12/20/blood-2018-06-860874?sso-checked=true">Blood</a>

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Study Observes an Increased Risk in Thromboembolic Events 30 Days Prior to Cancer Diagnosis

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A study published in Blood observed an increased risk of arterial thromboembolic events—including myocardial infarction and stroke—5 months prior to a cancer diagnosis. ...

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