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Immunotherapy in cancer has revolutionized cancer treatment and has become a universal answer to the question &ldquo;how can we treat cancer?&rdquo;&nbsp;However, checkpoint inhibitors&nbsp;(CPIs),&nbsp;a type of immunotherapy,&nbsp;is associated with a new group of immune-related adverse events (irAEs) in almost any organ system. In a recent study published in&nbsp;Nature Reviews Rheumatology, researchers outline these new questions and unmet needs that rheumatologists might be dealing with more.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Our new <a href="https://twitter.com/hashtag/Review?src=hash&amp;ref_src=twsrc%5Etfw">#Review</a> on Rheumatic immune-related adverse events from cancer immunotherapy is online now! <a href="https://twitter.com/LCalabreseDO?ref_src=twsrc%5Etfw">@LCalabreseDO</a> Check it out at <a href="https://t.co/eA0IpaAQ4o">https://t.co/eA0IpaAQ4o</a> <a href="https://t.co/u4GctmV37d">pic.twitter.com/u4GctmV37d</a>
&mdash; NatRevRheumatol (@NatRevRheumatol) <a href="https://twitter.com/NatRevRheumatol/status/1035970570909900800?ref_src=twsrc%5Etfw">September 1, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>According to the review, treatment of&nbsp;irAEs&nbsp;often requires immunosuppression with glucocorticoids, which are sometimes administered&nbsp;with conventional synthetic or biologic disease-modifying drugs.&nbsp;And although&nbsp;rheumatoid&nbsp;irAEs&nbsp;are not as common as traditional&nbsp;irAEs, they are&nbsp;underdiagnosed and less well recognized&nbsp;which is half of the problem.&nbsp;The review also states that rheumatic&nbsp;irAEs&nbsp;seem to be nosologically distinct, occurring both early and late in response to CPI therapy. To make matters worse,&nbsp;a substantial proportion of them are chronic, persisting even after cessation of CPI therapy.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
irAEs from cancer IMMUNOTHERAPY should be the domain for RHEUMATOLOGISTS to lead in both research and care &ndash; WE DO MULTISYTEM AUTOIMMUNITY for a living!!!!! <a href="https://twitter.com/jhrheumatology?ref_src=twsrc%5Etfw">@jhrheumatology</a> <a href="https://twitter.com/CleClinicMD?ref_src=twsrc%5Etfw">@CleClinicMD</a> <a href="https://twitter.com/HealioRheum?ref_src=twsrc%5Etfw">@HealioRheum</a> <a href="https://twitter.com/HealioRheum?ref_src=twsrc%5Etfw">@HealioRheum</a> <a href="https://twitter.com/hashtag/CleClinicCancer?src=hash&amp;ref_src=twsrc%5Etfw">#CleClinicCancer</a> <a href="https://twitter.com/hashtag/immunotherapy?src=hash&amp;ref_src=twsrc%5Etfw">#immunotherapy</a> <a href="https://twitter.com/MikkaelSekeres?ref_src=twsrc%5Etfw">@MikkaelSekeres</a> <a href="https://twitter.com/VamsiVelcheti?ref_src=twsrc%5Etfw">@VamsiVelcheti</a> <a href="https://t.co/ltH5w8JzzY">https://t.co/ltH5w8JzzY</a>
&mdash; Leonard Calabrese (@LCalabreseDO) <a href="https://twitter.com/LCalabreseDO/status/1035982570104791041?ref_src=twsrc%5Etfw">September 1, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Rheumatic related adverse events seem to be nosologically distinct, occurring both early and late in response to Check points inh (CPI) therapy. A proportion of them are chronic, persisting even after cessation of CPI therapy. <a href="https://twitter.com/LCalabreseDO?ref_src=twsrc%5Etfw">@LCalabreseDO</a> <a href="https://twitter.com/CCalabreseDO?ref_src=twsrc%5Etfw">@CCalabreseDO</a> <a href="https://t.co/DBq61Gk740">https://t.co/DBq61Gk740</a>
&mdash; Reumatolog&iacute;a Clinic (@Reumaclinic) <a href="https://twitter.com/Reumaclinic/status/1036500878138716160?ref_src=twsrc%5Etfw">September 3, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>&ldquo;Rheumatologists must be prepared for&nbsp;irAEs&nbsp;and contribute to inter-professional teams in managing immunotherapy for patients with cancer,&rdquo; the researchers concluded.&nbsp;Check out&nbsp;an article on&nbsp;if a specific&nbsp;<a href="https://proddocwire.wpengine.com/docwire-pick/systemic-sclerosis-serum-biomarker/">serum biomarker could positively impact patient survival</a>.&nbsp;SOURCE:&nbsp;<a href="https://www.nature.com/articles/s41584-018-0074-9">Nature Reviews Rheumatology&nbsp;</a>

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