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Psoriatic arthritis, axial&nbsp;spondyloarthritis&nbsp;(SpA)&nbsp;and&nbsp;nonradiographic&nbsp;axial&nbsp;SpA, reactive arthritis,&nbsp;enteropathic&nbsp;arthritis and undifferentiated&nbsp;SpA&nbsp;are all inflammatory diseases that fall under &ldquo;SpA.&rdquo;&nbsp;Subtypes&nbsp;of&nbsp;the disease&nbsp;share clinical and immunological features, including joint inflammation; skin, gut and eye manifestations; and the absence of diagnostic autoantibodies; genetic factors are also&nbsp;shared by the diseases.&nbsp;&nbsp;The cause of&nbsp;SpA&nbsp;is still a subject of numerous research projects, but the research that has been done shows a clear role for the IL-17 pathway in the pathogenesis of&nbsp;SpA, according to a review study in&nbsp;Nature Reviews Rheumatology.&nbsp;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Our new <a href="https://twitter.com/hashtag/Review?src=hash&amp;ref_src=twsrc%5Etfw">#Review</a> on IL-17 in the immunopathogenesis of spondyloarthritis from the <a href="https://twitter.com/Taams_Lab?ref_src=twsrc%5Etfw">@Taams_Lab</a> is online now!<a href="https://twitter.com/hashtag/IL17?src=hash&amp;ref_src=twsrc%5Etfw">#IL17</a> <a href="https://twitter.com/hashtag/spondyloarthritis?src=hash&amp;ref_src=twsrc%5Etfw">#spondyloarthritis</a> <a href="https://twitter.com/hashtag/pathogenesis?src=hash&amp;ref_src=twsrc%5Etfw">#pathogenesis</a><a href="https://t.co/JdIoooYGLZ">https://t.co/JdIoooYGLZ</a> <a href="https://t.co/b803bI6Xke">pic.twitter.com/b803bI6Xke</a>
&mdash; NatRevRheumatol (@NatRevRheumatol) <a href="https://twitter.com/NatRevRheumatol/status/1017768148207104000?ref_src=twsrc%5Etfw">July 13, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Proud to see our review in Nature Reviews <a href="https://twitter.com/hashtag/Rheumatology?src=hash&amp;ref_src=twsrc%5Etfw">#Rheumatology</a> out today! Do have a read if you're interested in the role of IL-17 in <a href="https://twitter.com/hashtag/spondyloarthritis?src=hash&amp;ref_src=twsrc%5Etfw">#spondyloarthritis</a>! <a href="https://twitter.com/hashtag/Immunology?src=hash&amp;ref_src=twsrc%5Etfw">#Immunology</a> <a href="https://t.co/JisexSVAvs">https://t.co/JisexSVAvs</a>
&mdash; Dr Ushani, PhD &#128105;&zwj;&#128300;&#128105;&zwj;&#128188;&#128105;&zwj;&#128187; (@UshaniS) <a href="https://twitter.com/UshaniS/status/1017798157290352640?ref_src=twsrc%5Etfw">July 13, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F&nbsp;are all a part of the IL-17 family, with IL-17A being the&nbsp;best studied.&nbsp;According to the review, of the six family members, IL-17A has the strongest homology with IL-17F.&nbsp;In this review,&nbsp;researchers&nbsp;discuss how IL-17A and IL-17F and their cellular sources might contribute to the immunopathology of&nbsp;SpA.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Would you like to know all about <a href="https://twitter.com/hashtag/IL?src=hash&amp;ref_src=twsrc%5Etfw">#IL</a>-17 and <a href="https://twitter.com/hashtag/spondyloarthritis?src=hash&amp;ref_src=twsrc%5Etfw">#spondyloarthritis</a>? Read our latest review out today in <a href="https://twitter.com/NatRevRheumatol?ref_src=twsrc%5Etfw">@NatRevRheumatol</a> ! <a href="https://t.co/e885U4KGg1">https://t.co/e885U4KGg1</a>
&mdash; Taams Lab (@Taams_Lab) <a href="https://twitter.com/Taams_Lab/status/1017784560170491904?ref_src=twsrc%5Etfw">July 13, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Source: <a href="https://www.nature.com/articles/s41584-018-0044-2">Nature Reviews Rheumatology</a>

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IL-17 Pathway in the Pathogenesis of Spondyloarthritis

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Psoriatic arthritis, axial spondyloarthritis (SpA) and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA are all ...

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