Kaitlyn D’Onofrio

DocwireNews

In a new study, gastric banding surgery was equitable to metformin in preserving&nbsp;&beta;-cell function&nbsp;in&nbsp;moderately obese patients with impaired glucose tolerance (IGT) or recently diagnosed&nbsp;obese type 2 diabetes (T2D) patients.&nbsp;The study included 88 people aged between 21 and 65 years old with a body mass index (BMI) between 30 and 40 kg/m2&nbsp;with&nbsp;IGT or&nbsp;diabetes known for less than one year. Patients were randomly assigned to gastric binding or metformin for two years. The gastric band group received adjustments every two months for the first year and then every three months for the second year based on symptoms and weight change. At baseline, one year and two years,&nbsp;patients received&nbsp;hyperglycemic clamps (11.1 mmol/L)&nbsp;and&nbsp;arginine injection&nbsp;(&gt;&nbsp;25 mmol/L).&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Gastric banding, metformin &ldquo;equal&rdquo; for slowing early T2DM progression: <a href="https://t.co/EUB8WUWLoJ">https://t.co/EUB8WUWLoJ</a> via ACS Surgery News
&mdash; American College of Surgeons (@AmCollSurgeons) <a href="https://twitter.com/AmCollSurgeons/status/1048574898963193856?ref_src=twsrc%5Etfw">October 6, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>After two years, the gastric banding group lost significantly more weight than the metformin group (10.7 kg vs 1.7 kg;&nbsp;P&nbsp;&lt; 0.01). The band group also had greater incidence of insulin sensitivity (45%) than the metformin cohort (25%) (P&nbsp;= 0.30 between groups). Both groups&nbsp;saw a slight decrease in steady-state C-peptide when adjusted for insulin sensitivity (P&nbsp;= 0.34 between groups). The metformin group saw a significant decrease in&nbsp;argenine&nbsp;at maximum glycemic potentiation&nbsp;adjusted for insulin sensitivity (P&nbsp;= 0.002) but not the band group (P&nbsp;= 0.25 between groups). The band group saw drops in&nbsp;HbA1c&nbsp;at one and two years (P&nbsp;&lt; 0.004) but the metformin only saw a decrease at one year (P&nbsp;&lt; 0.01) (P&nbsp;&gt; 0.14 between groups). At two years,&nbsp;normoglycemia was present in&nbsp;22% of the band group and 15% of the metformin group (P&nbsp;= 0.66 between groups).&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
New results from the <a href="https://twitter.com/NIDDKgov?ref_src=twsrc%5Etfw">@NIDDKgov</a>-funded <a href="https://twitter.com/hashtag/RISEstudy?src=hash&amp;ref_src=twsrc%5Etfw">#RISEstudy</a> BetaFat trial show that gastric banding is equally effective as metformin in slowing progression of <a href="https://twitter.com/hashtag/prediabetes?src=hash&amp;ref_src=twsrc%5Etfw">#prediabetes</a> and early type 2 <a href="https://twitter.com/hashtag/diabetes?src=hash&amp;ref_src=twsrc%5Etfw">#diabetes</a> <a href="https://t.co/87O7ZCewW6">https://t.co/87O7ZCewW6</a> <a href="https://twitter.com/RISEstudy?ref_src=twsrc%5Etfw">@RISEstudy</a> <a href="https://twitter.com/EASDnews?ref_src=twsrc%5Etfw">@EASDnews</a> <a href="https://twitter.com/hashtag/EASD2018?src=hash&amp;ref_src=twsrc%5Etfw">#EASD2018</a> <a href="https://twitter.com/hashtag/T2D?src=hash&amp;ref_src=twsrc%5Etfw">#T2D</a> <a href="https://t.co/V5QQie7Mch">pic.twitter.com/V5QQie7Mch</a>
&mdash; NIDDK (@NIDDKgov) <a href="https://twitter.com/NIDDKgov/status/1047507853462949888?ref_src=twsrc%5Etfw">October 3, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>The study results were published in&nbsp;Diabetes Care.&nbsp;&ldquo;Both interventions resulted in about 50% improvements in insulin sensitivity at 1 year, which was attenuated at 2 years,&rdquo;&nbsp;said&nbsp;study&nbsp;author&nbsp;Thomas Buchanan, MD, of the University of Southern California, Los Angeles,&nbsp;while presenting at the annual meeting of the European Association for the Study of Diabetes.&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
New results from the RISE Consortium, show that people with prediabetes or new-onset <a href="https://twitter.com/hashtag/T2D?src=hash&amp;ref_src=twsrc%5Etfw">#T2D</a> who had gastric banding, a type of bariatric surgery for weight loss, had similar stabilization of their disease to those who took metformin alone. <a href="https://twitter.com/hashtag/RISEstudy?src=hash&amp;ref_src=twsrc%5Etfw">#RISEstudy</a> <a href="https://t.co/YYeEYRrAUu">https://t.co/YYeEYRrAUu</a> <a href="https://t.co/iDheOu4q4V">pic.twitter.com/iDheOu4q4V</a>
&mdash; RISE Research Group (@RISEstudy) <a href="https://twitter.com/RISEstudy/status/1047471807874457601?ref_src=twsrc%5Etfw">October 3, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><a href="https://proddocwire.wpengine.com/abstracts/prediabetes-metformin-type-2/">Review of Metformin Use for Type 2 Diabetes Prevention</a>&nbsp;<a href="https://proddocwire.wpengine.com/cardiology/metformin-and-amp-kinase-activation-increase-expression-of-the-sterol-transporters-abcg5-8-atp-binding-cassette-transporter-g5-g8-with-potential-antiatherogenic-consequenceshighlights-basic-science/">Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences&nbsp;Highlights [Basic Sciences]</a>&nbsp;<a href="https://proddocwire.wpengine.com/general/effects-of-metformin-on-cell-growth-and-ampk-activity-in-pituitary-adenoma-cell-cultures-focusing-on-the-interaction-with-adenylyl-cyclase-activating-signals/">Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals</a>Sources:&nbsp;<a href="http://care.diabetesjournals.org/content/early/2018/10/03/dc18-1662">Diabetes Care</a>,&nbsp;<a href="https://www.mdedge.com/clinicalendocrinologynews/article/176467/diabetes/gastric-banding-metformin-equal-slowing-early-t2dm">Clinical Endocrinology News</a>

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Gastric Banding and Metformin Have Similar Effects on β-cell Function in Some Type 2 Diabetes Patients

Diabetes

In a new study, gastric banding surgery was equitable to metformin in preserving β-cell function in moderately obese patients with impaired glucose tolerance (IGT) or ...

Gastric Banding and Metformin Have Similar Effects on β-cell Function in Some Type 2 Diabetes

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