Charlotte Robinson

DocwireNews

Sharlene Greenwood and others studied the clinical and economic effects of a physical activity digital health intervention and reported results at the International Society of Nephrology World Congress of Nephrology 2024. They assigned 340 UK adults with chronic kidney disease (CKD) to either the Kidney BEAM intervention or a waiting list control group. Between baseline and 24 weeks, they measured the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS), the KDQoL-SF1.3 Physical Component Summary, and the European Quality of Life 5 dimension, 3 level (EQ5D-3L) utility score; they measured health care utilization at the same points.They analyzed outcomes with an intention-to-treat (Last Observation Carried Forward) approach using an analysis of covariance model, with baseline measures and age as covariates. They also completed per-protocol analyses to assess efficacy under ideal conditions.At 24 weeks, 229 participants completed the trial (Kidney BEAM: n=93; waiting list control: n=136). All 340 randomized participants were included in the intention-to-treat analyses. At 24 weeks there was a significant difference in mean adjusted change in KDQoL MCS score between the Kidney BEAM and waiting list control groups of 5.9 (95% CI, 4.4-7.5) arbitrary units (P&lt;.0001). KDQoL burden of kidney disease (P=.0017), quality of social interaction (P&lt;.0001), sleep (P&lt;.0001), physical functioning (P=.0003), role physical (P=.014), pain (P=.0002), general health (P=.0018), emotional well-being (P&lt;.0001), role emotional (P=.0058), social function (P&lt;.0001), and energy/fatigue (P&lt;.0001) all improved in favor of Kidney BEAM.There also was a significant mean adjusted change in the EQ5D-3L utility score of 1 (95% CI, 0.007-0.130) unit (P&lt;.0001) in favor of Kidney BEAM. Data from the adjusted base-case within-trial analysis found a 93% and 98% chance of Kidney BEAM being cost-effective compared with the control at a willingness to pay of &pound;20,000 and &pound;30,000 per quality-adjusted life-year gained.Source: <a href="https://doi.org/10.1016/j.ekir.2024.02.1415" target="_blank" rel="noopener">KI Reports</a>

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Latest News

Effects of a Physical Activity Intervention for CKD

WCN 2024

Researchers uncovered clinical and economic of the Kidney BEAM physical activity digital health intervention for chronic kidney disease (CKD). 

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