Rebecca Araujo

DocwireNews

Therapy with bortezomib and dexamethasone (BDex) achieved more rapid and deeper clonal responses compared with a regimen of cyclophosphamide, thalidomide, and dexamethasone (CTD) for treatment of amyloid light-chain (AL) amyloidosis, according to a <a href="https://www.sciencedirect.com/science/article/pii/S0147027220301720?via%3Dihub">study</a> published in Current Problems in Cancer.AL amyloidosis is an immune system disorder marked by the production of abnormal antibodies called light chains. Currently, both CTD and BDex regimens are recommended as primary treatment options for AL amyloidosis, but a study comparing the two therapies had not previously been conducted.Researchers from Xijing Hospital in Shaanxi, China conducted a retrospective cohort study of 81 patients with biopsy-confirmed AL amyloidosis, all of whom were treated with BDex (n=39) or CTD (n=42). Overall response to treatment was 86% versus 91% in the CTD and BDex groups, respectively. A complete response was achieved in 56% of patients receiving CTD compared with 71% of patients who received BDex, based on an intention-to-treat (ITT) analysis. One- and two-year overall survival (OS) was 90.2% and 81.7%, respectively, for the CTD cohort, and 87.6% and 82.7%, respectively, with BDex.Overall, the BDex regimen induced significantly deeper and faster hematologic response compared with CTD, although there was no statistically significant difference in OS (ITT analysis, P=0.24; six-month landmark analysis, P=0.48).BDex was also associated with significantly improved survival in patients with advanced disease (P=0.009), although patients treated with this regimen reported more episodes of severe hematologic toxicity and diarrhea.&ldquo;CTD and BDex are effective treatments for Chinese patients with AL amyloidosis, but [the] BDex regimen appears superior to CTD in achieving a more rapid and deeper clonal response and in improving OS in patients with advanced disease,&rdquo; the researchers concluded.

Roger Rodby, MD

Joel M. Topf, MD, FACP

Seldin Award Winner Advocates Online Education

NKF Spring Clinical Meetings 2025

Hatem Soliman, MD

The Future of Dendritic Cell Vaccines in HER2+ Breast Cancer: Toward De-Escalation of Chemotherapy

HER2 Breast Cancer

Jordana Jampel

Mechanism of Positive Association Between Parkinson’s Disease and Melanoma Revealed in New Research

Melanoma

Latest News

CTD Versus BDex for Treatment of Light-Chain Amyloidosis

Oncology

Therapy with bortezomib and dexamethasone (BDex) achieved more rapid and deeper clonal responses compared with a regimen of cyclophosphamide, thalidomide, and dexamethasone ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe