Patrick Daly

DocwireNews

Mutated Stromal Antigen 2 (mSTAG2) coding genes are more common in elderly men and patients with myelodysplastic syndromes (MDS), according to a study presented at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting. The mutations may play a role in disease progression with certain co-mutations.Researchers, led by Bahga Katamesh and colleagues, retrospectively identified and screened 70 patients with mSTAG2 (median age, 72, 79% male). The population of interest all had next-generation sequencing (NGS) performed at Mayo Clinic between 2018-2021.The results showed that STAG2&nbsp;mutations were nonsense, frameshift, and splice site in 50%, 37%, and 13% of patients, respectively. The most common co-mutations observed were&nbsp;ASXL1&nbsp;(66%),&nbsp;SRSF2&nbsp;(37%),&nbsp;TET2&nbsp;(36%),&nbsp;RUNX1&nbsp;(29%),&nbsp;IDH2&nbsp;(21%),&nbsp;BCOR&nbsp;(20%) and&nbsp;U2AF1&nbsp;(16%) while least common mutations wereTP53,&nbsp;SETBP&nbsp;and&nbsp;ZRSR2&nbsp;(1% each). The analysis also found that patients with an isolated mSTAG2&nbsp;had better overall survival (OS) than co-mutated patients (p= 0.04), while the type of&nbsp;STAG2&nbsp;mutation had no impact on OS (p= 0.3).The researchers concluded &ldquo;mSTAG2&nbsp;was more common in elderly males and MDS diagnosis.&nbsp;mSTAG2&nbsp;was uncommon as an isolated mutation, indicating a possible role in disease progression with preferred certain co-mutations.&rdquo;

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Characterizing Mutated STAG2 Myeloid Neoplasms

ASCO 2022

Mutated Stromal Antigen 2 (mSTAG2) coding genes are more common in elderly men and patients with myelodysplastic syndromes (MDS), according to a study presented at the 2022 ...

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