Patrick Daly

DocwireNews

Previous trials suggested continuous positive airway pressure (CPAP) therapy did not yield a cardiovascular benefit in patients with coronary artery disease (CAD) and obstructive sleep apnea (OSA); however, researchers noted enrollment criteria that excluded patients with OSA with excessive daytime sleepiness (EDS) may have led to the null findings, given those patients could be more likely to benefit from CPAP.Lead author, Christine Eulenburg, and colleagues performed a secondary analysis of the RICCADSA trial to examine the effect of concurrent EDS in patients with CAD and OSA, and whether the cardiovascular effects of CPAP therapy differed between patients with or without EDS. Based on their findings, investigators concluded adverse cardiovascular outcomes were not meaningfully different between patients with or without EDS. The study was presented in Annals of the American Thoracic Society.<h2>Lack of CPAP Benefit Persists in OSA With EDS</h2>The analysis included 155 patients with CAD and OSA (defined by apnea-hypopnea index &ge;15/h) with EDS (defined by Epworth Sleepiness Scale &ge;10) who were assigned to CPAP and 244 patients without EDS who were randomized between CPAP and no CPAP. Participants in the non-CPAP group or nonadherent participants in the CPAP group were compared with adherent patients at year 1.Inverse probability of treatment weighting was applied to mimic randomization of EDS. The primary end point was the first instance of repeat revascularization, myocardial infarction, stroke, or cardiovascular mortality.At a median follow-up of 52.2 months, the incidences of the primary end point events did not significantly differ between the EDS and non-EDS groups overall. Authors did note, however, that patients who were adherent to CPAP without EDS were associated with significantly decreased cardiovascular risk compared with patients with EDS (adjusted hazard ratio, 0.41; 95% CI, 0.20-0.85; P=.02).The study&rsquo;s authors summarized that &ldquo;adverse cardiovascular outcomes did not differ by <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506799/" target="_blank" rel="noopener">degrees of EDS</a> for patients with CAD with OSA who were untreated or nonadherent to treatment,&rdquo; and that CPAP adherence was associated with reduced adverse outcomes in participants without EDS.Related: <a href="https://docwirenews.com/post/an-automated-approach-to-calculating-hypoxic-burden-based-on-oximetry">An Automated Approach to Calculating Hypoxic Burden Based on Oximetry </a>

Jordana Jampel

Distant Brain Metastases in Cutaneous Melanoma May Be Mitigated With Multiple Pathway Inhibitors

Melanoma

Eric Bergson, MD

Rob Dillard

The Role of Multidisciplinary Care in Head and Neck Cancer

Head and Neck Cancer

Sara Nunnery, MD, MSCI

Trastuzumab Deruxtecan in HER2-Low Breast Cancer: Who’s the Right Patient?

HER2 Breast Cancer

Latest News

CAD and OSA With or Without Excessive Daytime Sleepiness on CPAP

Sleep Disorders

CPAP therapy did not provide a cardiovascular benefit in patients with CAD and OSA, regardless of excessive daytime sleepiness status.

CAD and OSA With or Without Excessive Daytime Sleepiness on CPAP 

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HR Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe