DocWire News Editors

DocwireNews

A study analyzed intravitreal aflibercept treatment and its impact on diabetic retinopathy severity in visual function in patients with proliferative diabetic retinopathy (PDR) who did not have diabetic macular edema (DME).A total of 40 patients with PDR without DME were randomized to receive aflibercept 2 mg injections either monthly or quarterly and treated for a 12-month period. An Optos 200Tx device was used to perform ultra-wide field fundus imaging on patients, which included pseudocolor and fluorescein angiography. Certified reading center graders used the diabetic retinopathy severity scale (DRSS) to assess retinopathy severity at baseline and at six and 12 months; the baseline and 12-month DRSS scores were correlated with the 25- and 39-item Visual Function Questionnaire (VFQ) scores.The mean patient age was 48.2 years (range, 25-75 years) and diabetes duration was 16.1 years (range, 2-36 years); mean hemoglobin A1C was 8.8%. From baseline to month 12, both the monthly and quarterly aflibercept groups experienced significant DRSS regression (P&lt;0.001). At six-month follow-up, regression in the monthly group was significantly greater than that of the quarterly group (P=0.019), but by 12-month follow-up, the between-group difference was no longer statistically significant (P=0.309). After 12 months, there were no significant between-group differences in mean VFQ-25 (P=0.947) and VFQ-39 (P=0.921) composite scores. Twelve-month improvements in mean VFQ-25 and VFQ-39 composite scores were significantly associated with DRSS improvement (R=0.384,&nbsp;P=0.039; and R=0.361,&nbsp;P=0.046, respectively).&ldquo;In this study of eyes with PDR without DME, both monthly and quarterly aflibercept injection groups showed significant improvement in diabetic retinopathy severity at month 12 compared with baseline. The improvement in DRSS was associated with an improvement in VFQ composite score,&rdquo; the study authors summarized.

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

Aflibercept in Diabetic Retinopathy Visual Function Without DME

Ophthalmology

A study analyzed intravitreal aflibercept treatment and its impact on diabetic retinopathy severity in visual function in patients with proliferative diabetic retinopathy ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Cardiology

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe