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HER2-Low Metastatic

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Trastuzumab Deruxtecan in HER2-Low Breast Cancer: Who’s the Right Patient?

Sara Nunnery, MD, director of breast cancer research at Tennessee Oncology, outlines key considerations when deciding whether to offer trastuzumab deruxtecan to patients with HER2-low or HER2-ultralow metastatic breast cancer. Dr. Nunnery explains how clinical factors, treatment setting (IV vs oral), and patient preferences around quality of life all play a role in determining the ideal candidate for this therapy.

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April 28, 2025