ASH Annual Meeting 2022

cyclophosphamide molecular formula

PTCy, Abatacept, and Tacrolimus for GVHD Prophylaxis

Haploidentical blood and marrow transplantation (BMT) has significantly increased the number of eligible hematopoietic stem cell donors; however, the...
Baricitinib vial with syringe in clean tray

Baricitinib Plus Standard GVHD Prophylaxis: Phase 1 Results

Researchers, led by Mark A. Schroeder, MD, conducted a single-arm, open-label phase 1 trial to evaluate the safety of...
doctor with patient in office explaining survey

The Lasting Impact of Surviving Severe aGVHD

Patients who recover from grade 3-4 acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic cell transplantation (HCT) demonstrated greater risk...
space-filling model of ruxolitinib molecule

Impact of Ruxolitinib Initiation Timing

Studies suggest that between 35% and 60% of patients with acute graft-versus-host disease (aGVHD) become resistant to corticosteroids. Prolonged...
3d illustration of human gastrointestinal tract on dark blue background

Pilot Data on Fecal Microbiotherapy for Acute GI GVHD

In a presentation at the 64th ASH Annual Meeting and Exposition, researchers presented findings from a pilot study on...
diagram of t-cell activation process

PRMT5 Identified as Potential GVHD Treatment Target

Previously, Katiri Snyder and colleagues determined that the enzyme protein arginine methyltransferase 5 (PRMT5) was upregulated in acute graft-versus-host...
corticosteroid bottle and syringe on pink background

Ruxolitinib With Corticosteroids in Pediatric GVHD

In a presentation at the 64th ASH Annual Meeting and Exposition, Franco Locatelli, MD, presented the first evidence reported...
blue latex gloved-hand holding blood tube with separated plasma

Belumosudil Significantly Affects IST Serum Concentrations

Recently, the novel Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor, belumosudil, was approved for the treatment of chronic...
Malignant bone marrow photomicrograph

Adding Itacitinib to Conventional GVHD Prophylaxis

In a recent study, researchers from the Hope National Medical Center in Duarte, California, evaluated the safety and efficacy...
Mycophenolate chemical formula

A New Standard for Graft-Versus-Host Disease Prevention

For years, the standard prophylaxis for graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT) has been a calcineurin...
prednisone tablet on gray surface

Itacitinib Potentially Superior to Corticosteroids in GVHD

In a phase 2 trial, presented at the 64th ASH Annual Meeting and Exposition, researchers compared itacitinib monotherapy against...

Featured on DocWire

Curated Journal Abstracts

Advertisement