Germline Pathogenic Variants in Cancer Susceptibility Genes in White Versus Black Women

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In the Hospital, Portrait Shot of Topless Latin Female Patient with Short Hair Undergoing Mammography Screening Procedure. Healthy Young Female Does Cancer Preventive Mammogram Scan in Radiology Room.

A study published in JAMA Oncology found no differences in the prevalence of germline pathogenic variants in white women versus Black women with breast cancer. The two groups did not largely differ in the prevalence of the 12 germline pathogenic variants. White women had a higher prevalence of pathogenic variants in CHEK2 than Black women, but a lower prevalence in BRCA2.