DocWire News Editors

DocwireNews

Results from a new analysis suggested that carpal tunnel syndrome was linked with amyloid deposits at the time of carpal tunnel&nbsp;release&nbsp;surgery and could be suggestive of future&nbsp;<a href="https://proddocwire.wpengine.com/tag/cardiac-events/">cardiac&nbsp;amyloid-related&nbsp;events</a>.&nbsp;&nbsp;Researchers for the cross-section,&nbsp;prospective&nbsp;study included consecutive men &ge;50 years and women &ge;60 years of age who were&nbsp;undergoing&nbsp;carpal tunnel release surgery. The authors obtained biopsy specimens of the&nbsp;tenosynovial&nbsp;tissue and stained them with Congo red to&nbsp;determine&nbsp;the prevalence and type of&nbsp;<a href="https://proddocwire.wpengine.com/tag/cardiac-amyloidosis/">amyloid</a>&nbsp;deposits, if any. Biopsies found with amyloid deposits were further analyzed for other biomarkers indicating cardiac involvement. The study included a total of 98 patients.&nbsp;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Is carpal tunnel release surgery in amyloid patients an opportunity to screen for cardiac amyloid? <a href="https://t.co/0dioKdaaKm">https://t.co/0dioKdaaKm</a> <a href="https://twitter.com/hashtag/JACC?src=hash&amp;ref_src=twsrc%5Etfw">#JACC</a> <a href="https://twitter.com/maz_hanna?ref_src=twsrc%5Etfw">@maz_hanna</a> <a href="https://twitter.com/BrettSperryMD?ref_src=twsrc%5Etfw">@BrettSperryMD</a> <a href="https://t.co/CMaV1Ve7n5">pic.twitter.com/CMaV1Ve7n5</a>
&mdash; JACC Journals (@JACCJournals) <a href="https://twitter.com/JACCJournals/status/1052329610325753856?ref_src=twsrc%5Etfw">October 16, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>According to the results, 10 (10.2%) of patients had a positive biopsy for amyloid presence. Two patients&nbsp;were&nbsp;diagnosed with&nbsp;hereditary&nbsp;amyloid transthyretin, two patients had cardiac involvement, and three patients were initiated on therapy.&nbsp;In&nbsp;patients with biopsy-diagnosed&nbsp;transthyretin&nbsp;<a href="https://proddocwire.wpengine.com/cardiology/amyloidosis-diagnoses-vary/">amyloid,</a>&nbsp;there was no difference in plasma transthyretin concentration.&nbsp;&nbsp;&ldquo;In a cohort of patients undergoing carpal tunnel release surgery, Congo red staining of&nbsp;tenosynovial&nbsp;tissue detected amyloid deposits in 10.2% of patients,&rdquo; the researchers concluded. &ldquo;Concomitant cardiac evaluation identified patients with involvement of the myocardium, allowing for implementation of disease-modifying therapy.&rdquo;&nbsp;<blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Honored to be involved in this multi-specialty effort that led to a detection of amyloid deposits in 10% of older patients undergoing carpal tunnel release surgery. Early diagnosis of <a href="https://twitter.com/hashtag/amyloidosis?src=hash&amp;ref_src=twsrc%5Etfw">#amyloidosis</a> is paramount. Proposed algorithm and thread below. 1/n <a href="https://t.co/larBBlMIj0">https://t.co/larBBlMIj0</a>
&mdash; Brett Sperry, MD (@BrettSperryMD) <a href="https://twitter.com/BrettSperryMD/status/1052411070864871424?ref_src=twsrc%5Etfw">October 17, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
A must read review! Amyloidosis and carpal tunnel syndrome &hellip; Thanks for sharing <a href="https://twitter.com/NadeenFaza?ref_src=twsrc%5Etfw">@NadeenFaza</a> <a href="https://t.co/9ILJ0hJMEc">https://t.co/9ILJ0hJMEc</a>
&mdash; Alma Sthela Arrioja, MD (@almasthela) <a href="https://twitter.com/almasthela/status/1052395555937226753?ref_src=twsrc%5Etfw">October 17, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Outstanding paper on <a href="https://twitter.com/hashtag/amyloidosis?src=hash&amp;ref_src=twsrc%5Etfw">#amyloidosis</a> and carpal tunnel syndrome! A must read! <a href="https://t.co/8lcOLa2WWj">https://t.co/8lcOLa2WWj</a> Congratulations <a href="https://twitter.com/BrettSperryMD?ref_src=twsrc%5Etfw">@BrettSperryMD</a> and team! <a href="https://twitter.com/JACCJournals?ref_src=twsrc%5Etfw">@JACCJournals</a> <a href="https://twitter.com/hashtag/ACCFIT?src=hash&amp;ref_src=twsrc%5Etfw">#ACCFIT</a> <a href="https://twitter.com/ACCmediacenter?ref_src=twsrc%5Etfw">@ACCmediacenter</a> <a href="https://twitter.com/ACCinTouch?ref_src=twsrc%5Etfw">@ACCinTouch</a> @ACCCardioEd <a href="https://twitter.com/hashtag/ACCimaging?src=hash&amp;ref_src=twsrc%5Etfw">#ACCimaging</a> <a href="https://twitter.com/AHAScience?ref_src=twsrc%5Etfw">@AHAScience</a> <a href="https://t.co/A9vwjwTu5j">pic.twitter.com/A9vwjwTu5j</a>
&mdash; Nadeen N. Faza, M.D. (@NadeenFaza) <a href="https://twitter.com/NadeenFaza/status/1052376500929003520?ref_src=twsrc%5Etfw">October 17, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Should older patients with carpal tunnel be screened for amyloid? Great study by <a href="https://twitter.com/BrettSperryMD?ref_src=twsrc%5Etfw">@BrettSperryMD</a> <a href="https://twitter.com/maz_hanna?ref_src=twsrc%5Etfw">@maz_hanna</a> in <a href="https://twitter.com/JACCJournals?ref_src=twsrc%5Etfw">@JACCJournals</a> <a href="https://t.co/6m1hQIbqPm">https://t.co/6m1hQIbqPm</a>
&mdash; Javid Moslehi (@CardioOncology) <a href="https://twitter.com/CardioOncology/status/1052319896657387520?ref_src=twsrc%5Etfw">October 16, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Should we screen carpal tunnel patients for cardiac amyloidosis?
&ndash; exciting study in <a href="https://twitter.com/JACCJournals?ref_src=twsrc%5Etfw">@JACCJournals</a> <a href="https://t.co/pX7tdWiudP">https://t.co/pX7tdWiudP</a><a href="https://twitter.com/hashtag/Cardiology?src=hash&amp;ref_src=twsrc%5Etfw">#Cardiology</a> <a href="https://twitter.com/hashtag/Cardiotwitter?src=hash&amp;ref_src=twsrc%5Etfw">#Cardiotwitter</a> <a href="https://twitter.com/hashtag/Amyloidosis?src=hash&amp;ref_src=twsrc%5Etfw">#Amyloidosis</a> <a href="https://t.co/V5NBBh0VfF">pic.twitter.com/V5NBBh0VfF</a>
&mdash; Konstantin Krychtiuk (@krychtiukmd) <a href="https://twitter.com/krychtiukmd/status/1052240530699153408?ref_src=twsrc%5Etfw">October 16, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
Brilliant paper <a href="https://twitter.com/BrettSperryMD?ref_src=twsrc%5Etfw">@BrettSperryMD</a> <a href="https://twitter.com/maz_hanna?ref_src=twsrc%5Etfw">@maz_hanna</a> Tenosynovial and Cardiac Amyloidosis in&nbsp;Patients Undergoing Carpal&nbsp;Tunnel&nbsp;Release <a href="https://t.co/6chGs3KsKU">https://t.co/6chGs3KsKU</a>
&mdash; Ashish Aneja MD FACC FAHA FASE FSCMR (@ash71us) <a href="https://twitter.com/ash71us/status/1052013261409914880?ref_src=twsrc%5Etfw">October 16, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Source:&nbsp;<a href="http://www.onlinejacc.org/content/72/17/2040?utm_medium=social&amp;utm_source=twitter_post&amp;utm_campaign=editors_insights&amp;utm_content=10.1016%2Fj.jacc.2018.07.092">JACC</a>

Jeffrey Perl, MD

Joel M. Topf, MD, FACP

Thoughts From the 2025 Lazarus Award Winner

NKF Spring Clinical Meetings 2025

Brandon Twyford

DESTINY-Breast09 Demonstrates First-Line Superiority of Enhertu Plus Pertuzumab in HER2-Positive Metastatic Breast Cancer

HER2 Breast Cancer

Trodelvy Plus Keytruda Significantly Improves Progression-Free Survival in PD-L1+ mTNBC, Phase III Data Show

Triple-Negative Breast Cancer

Latest News

Should Cardiac Amyloids Be Screened For After Carpal Tunnel Release Surgery?

Cardiology

Results from a new analysis suggested that carpal tunnel syndrome was linked with amyloid deposits at the time of carpal tunnel release surgery and could be suggestive of ...