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Rivaroxaban&nbsp;did&nbsp;not demonstrate superiority to aspirin for the prevention of stroke after an embolic stroke of&nbsp;unknown&nbsp;origin,&nbsp;according&nbsp;to results from new study published in the New England Journal of&nbsp;Medicine. The researchers enrolled&nbsp;a total of 7,213 patients with recent ischemic stroke presumed to be from cerebral embolism, but without arterial stenosis,&nbsp;lacune&nbsp;or an identified cardioembolic source. Patients were randomly assigned to receive either rivaroxaban or aspirin and were followed out to a median of 11 months (the study was terminated early due to a lack of observed benefit&nbsp;with regard to&nbsp;stroke risk and higher bleeding in the rivaroxaban arm). The first recurrence of stroke occurred in 172 patients in the rivaroxaban group compared to 160 in the aspirin group (p=0.52).&nbsp;Recurrent&nbsp;ischemic stroke was nearly the same in both groups. Major bleeding occurred in 62 patients in the rivaroxaban arm and in 23 patients in the aspirin arm (p&lt;0.001).&nbsp;&nbsp;Source: <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1802686">New England Journal of Medicine (NEJM)</a>&nbsp;

MarkAlain Déry, DO

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Rivaroxaban Not Superior to Aspirin for Preventing Stroke After Embolic Stroke of Unknown Origin

Cardiology

Rivaroxaban did not demonstrate superiority to aspirin for the prevention of stroke after an embolic stroke of unknown origin, according to results from new study ...

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