Preoperative CRT Versus Perioperative CT for Gastric Cancer: The TOPGEAR Study

At the ESMO Congress 2024, Trevor Leong, MD, of Peter MacCallum Cancer Centre, showcases the highly anticipated results of the TOPGEAR study, which sought to determine whether the addition of preoperative chemoradiotherapy to perioperative chemotherapy would improve pathological complete response rates and overall survival compared to perioperative chemotherapy alone in patients with resectable gastric/gastroesophageal junction adenocarcinoma.

While improving pathological outcomes, the addition of preoperative chemoradiotherapy to perioperative chemotherapy may not have added overall survival benefit.