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<p>Pooled cohort equations (PCEs) can predict 10-year atherosclerotic cardiovascular disease risk (ASCVD) when events identified by the Centers for Medicare and Medicaid Services (CMS) were factored in, according to data published in a new analysis in JAMA Internal Medicine.&nbsp;<span data-ccp-props='{"201341983":0,"335551550":1,"335551620":1,"335559739":160,"335559740":259}'>&nbsp;</span><p>The researchers looked at a cohort 19,995 women and evaluated the predictive accuracy of PCEs in the Women&rsquo;s Health Initiative, the effects of aspirin and statins,&nbsp;and also&nbsp;looked at additional ASCVD events reported to CMS. The authors defined atherosclerotic cardiovascular disease as myocardial infarction, stroke, or&nbsp;cardiovascular&nbsp;death for the study outcome. The median follow-up was 10 years.&nbsp;<span data-ccp-props='{"201341983":0,"335551550":1,"335551620":1,"335559739":160,"335559740":259}'>&nbsp;</span></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">Study Conclusion: "Without including surveillance for ASCVD using CMS, observed risks in WHI were lower than predicted by PCE as noted in other US cohorts but risks were better aligned after including CMS events." [I will note that PCE overestimated risk in MESA, which used CMS.] <a href="https://t.co/VtDFEaxqDt">https://t.co/VtDFEaxqDt</a></p>
<p>&mdash; Erin D. Michos, M.D. (@ErinMichos) <a href="https://twitter.com/ErinMichos/status/1021792065162760193?ref_src=twsrc%5Etfw">July 24, 2018</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">And here is the link to Dr. Mora's paper in <a href="https://twitter.com/JAMAInternalMed?ref_src=twsrc%5Etfw">@JAMAInternalMed</a> : Evaluation of the Pooled Cohort Risk Equations for Cardiovascular Risk Prediction in a Multiethnic Cohort From the Women&rsquo;s Health Initiative <a href="https://t.co/OQyO4uZyjA">https://t.co/OQyO4uZyjA</a>   <a href="https://twitter.com/hashtag/cvPrev?src=hash&amp;ref_src=twsrc%5Etfw">#cvPrev</a></p>
<p>&mdash; Erin D. Michos, M.D. (@ErinMichos) <a href="https://twitter.com/ErinMichos/status/1021790394412163074?ref_src=twsrc%5Etfw">July 24, 2018</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><p>According to the study data, a total of 1,236 atherosclerotic cardiovascular disease events occurred over 10 years. Women&rsquo;s Health Initiative-adjudicated observed risks were lower than predicted, with small changes after adjusting for statin and aspirin use. In Medicare patients over 65 years of age, Women&rsquo;s Health&nbsp;Initiative-adjudicated risks were lower than&nbsp;predicted&nbsp;but&nbsp;were more closely aligned with observed risk when events ascertained by CMS were included. These results were also seen across racial and ethnic groups.<span data-ccp-props='{"201341983":0,"335551550":1,"335551620":1,"335559739":160,"335559740":259}'>&nbsp;</span></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">Pooled Cohort ASCVD Risk Calculator performs quite well when you capture most of the events.  <a href="https://t.co/xdOLAatLcR">https://t.co/xdOLAatLcR</a></p>
<p>&mdash; Karol Watson (@kewatson) <a href="https://twitter.com/kewatson/status/1021767104633204736?ref_src=twsrc%5Etfw">July 24, 2018</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">observed risks in the WHI were lower than predicted by PCE as noted in several other US cohorts, but risks were better aligned after including CMS events. <a href="https://t.co/iKkMe8gpMl">https://t.co/iKkMe8gpMl</a></p>
<p>&mdash; @investigando (@rocatanho) <a href="https://twitter.com/rocatanho/status/1021609951893045248?ref_src=twsrc%5Etfw">July 24, 2018</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><p>DocWire&nbsp;News has previously written about&nbsp;<a href="https://proddocwire.wpengine.com/cardiology/association-between-pregnancy-and-platelet-count/">cardiovascular issues facing women</a>, such <a href="https://proddocwire.wpengine.com/cardiology/cardiovascular-risks-associated-with-pre-eclampsia/">as&nbsp;preeclampsia and increased risk</a>, as well as other topics such as&nbsp;<a href="https://proddocwire.wpengine.com/cardiology/review-marital-status-risk-cardiovascular-disease/">marital status and&nbsp;cardiovascular&nbsp;risk.</a>&nbsp;<span data-ccp-props='{"201341983":0,"335551550":1,"335551620":1,"335559739":160,"335559740":259}'>&nbsp;</span></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">Were the ASCVD PCEs right all along? The original concerns about the ASCVD PCE's accuracy came from 3 studies that used patient event reporting. Now, that finding almost disappears after looking for events more thoroughly. Whoah. <a href="https://t.co/IDl4i2gnQC">https://t.co/IDl4i2gnQC</a></p>
<p>&mdash; Jeremy Sussman (@JeremySussman) <a href="https://twitter.com/JeremySussman/status/1021513239106973697?ref_src=twsrc%5Etfw">July 23, 2018</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">Re-evaluation of the PCE miscalibration issue in <a href="https://twitter.com/JAMAInternalMed?ref_src=twsrc%5Etfw">@JAMAInternalMed</a> shows that after accounting for events from administrative data from CMS, calibration in Women's Health Initiative isn't so bad.<a href="https://t.co/mu5MuQmktD">https://t.co/mu5MuQmktD</a><a href="https://twitter.com/skathire?ref_src=twsrc%5Etfw">@skathire</a> <a href="https://twitter.com/khurramn1?ref_src=twsrc%5Etfw">@khurramn1</a> <a href="https://twitter.com/JeremySussman?ref_src=twsrc%5Etfw">@JeremySussman</a> <a href="https://twitter.com/ProfHayward?ref_src=twsrc%5Etfw">@ProfHayward</a></p>
<p>&mdash; Venk Murthy MD PhD (@venkmurthy) <a href="https://twitter.com/venkmurthy/status/1021509355399774208?ref_src=twsrc%5Etfw">July 23, 2018</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">Another point against HIPAA. "Post-HIPAA, hospitals and institutions have many deterrents to providing medical records to research studies (eg, fear of litigation, extra labor involved for retrieval of medical records, greater number of research studies)." <a href="https://t.co/mN2POoIJJK">https://t.co/mN2POoIJJK</a></p>
<p>&mdash; Jeff Wessler, MD (@jwessler) <a href="https://twitter.com/jwessler/status/1021492188721635328?ref_src=twsrc%5Etfw">July 23, 2018</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><p><span class="TextRun SCXW231510670" lang="EN-US" xml:lang="EN-US"><span class="NormalTextRun SCXW231510670">Source:<a href="https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2688070"> JAMA Internal Medicine</a></span></span><span class="EOP SCXW231510670" data-ccp-props='{"201341983":0,"335559739":160,"335559740":259}'>&nbsp;</span></p><p>&nbsp;</p></p>


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Pooled Cohort Equations Can Predict 10-year Atherosclerotic Cardiovascular Disease Risk

Cardiology

Pooled cohort equations (PCEs) can predict 10-year atherosclerotic cardiovascular disease risk (ASCVD) when events identified by the Centers for Medicare and Medicaid Services ...

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