Despite its use as a common prognostic biomarker for gastric cancer, the predictive values of neutrophil-to-lymphocyte ratios (NLRs) still remain unclear for patients who undergo neoadjuvant chemotherapy (NAC).
A recent systematic review and meta-analysis utilized multiple online databases to evaluate the relationship between NLR and the prognosis of patients with gastric cancer who receive NAC.
Online databases including PubMed and Cochrane Library were utilized to collect data from relevant studies on the interaction of NLR with clinical outcomes. Outcomes analyzed included progression-free survival (PFS), relapse-free survival, disease-free survival (DFS), and overall survival (OS).
The hazard ratio (HR) and corresponding 95% confidence interval (CI) were used for estimation.
Data from a total of 852 patients and 9 cohort studies were utilized. The data analysis found a significant link between high NLR and reduced rates of OS (HR=1.76; 95% CI: 1.22-2.54, P=.003), relapse-free survival (HR=3.73; 95% CI: 1.74-7.96, P=.0007), and PFS (HR=2.32; 95% CI: 1.42-3.81, P=.0008)
No significant association between NLR and DFS was found. NLR was found to effectively predict the OS of patients with gastric cancer undergoing NAC at various detection times and NLR thresholds.
© 2025 Mashup Media, LLC, a Formedics Property. All Rights Reserved.