DocWire News Editors

DocwireNews

Georgia Bowen was born via emergency cesarean section and was found to have severe cardiac defects from a heart attack likely to have occurred in the womb. With a large portion of her cardiac muscle dead, doctors kept her alive with machinery and transported her to Boston Children&rsquo;s Hospital to attempt the first mitochondrial transplant treatment for a heart attack.Studies conducted on animals at Boston Children&rsquo;s Hospital and various other research centers has shown that transporting mitochondria from healthy tissue to damaged heart tissue can restore cardiac function, however the only studies in humans testing this method were effective in reviving cardiac tissue in infants following surgery. Georgia&rsquo;s cardiac damage resulting from her heart attack was much more profound than that arising from temporary blood loss during operation, making the transplant highly experimental in her case.Dr. James McCully had conceived the concept of mitochondrial transplant as a means of restoring function in heart tissue that has been deprived of oxygen through testing with pig hearts. Hearing of his work, Dr. Emani teamed up with Dr. McCully to attempt the transplant in infants with cardiac damage after surgery who were put on an extracorporeal membrane oxygenator (Ecmo) to survive.&ldquo;It was amazing.&rdquo;Using tissue from the patient&rsquo;s neck, the doctors isolated one billion mitochondria and injected them into her damaged cardiac tissue. Two days after the operation the patient&rsquo;s heart resembled that of a healthy infant. These profound results led to the scientists performing the transplant in 11 other infants, all of whom able to discontinue Ecmo use after treatment. 3 of these infants died, however Dr. Emani attributes this to delayed treatment and infection. Death rates in infants who did not receive the treatment was 65%, with over a third of the surviving babies on heart transplant list.Unfortunately, Georgia&rsquo;s heart tissue was dead at the time of transplant, however the doctors were able to install an implant that allows the heart to beat. She can breath and drink breast milk through a tube on her own, and her heart is showing signs of healing.Dr. Emani and his peers believe that injecting the mitochondria into blood vessels leading to the heart has the same effect as injecting them directly into the cardiac tissue, however they recognize that clinical trials must be conducted prior to confirming this claim.<blockquote class="twitter-tweet" data-lang="en">
<a href="https://twitter.com/hashtag/Mitochondria?src=hash&amp;ref_src=twsrc%5Etfw">#Mitochondria</a> <a href="https://twitter.com/hashtag/transplants?src=hash&amp;ref_src=twsrc%5Etfw">#transplants</a> &ndash; sounds like science fiction bit apparently they work &ndash; they should be renamed as the Lazarus organelles. <a href="https://t.co/cJdnY6frqt">https://t.co/cJdnY6frqt</a> <a href="https://t.co/k9cKTem5KD">https://t.co/k9cKTem5KD</a>
&mdash; Norman Briffa MD ? (@Chestcracker) <a href="https://twitter.com/Chestcracker/status/1017040738981437446?ref_src=twsrc%5Etfw">July 11, 2018</a>
</blockquote><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>Source: <a href="https://futurism.com/mitochondrial-transplant-damaged-hearts/">NY Times</a>

Bradley Marder, MD

Joel M. Topf, MD, FACP

Gout Studies: Transplant Waitlisting and Bone Erosion

NKF Spring Clinical Meetings 2025

Jayme Locke, MD, MPH

The Promise of Xenotransplantation

Leah Lawrence

Real-World Data Backs Invasive DFS as Surrogate Endpoint for OS in EBC

HR Breast Cancer

Latest News

Experimental Mitochondrial Transplant in Newborn with Severe Heart Damage

Cardiology

Georgia Bowen was born via emergency cesarean section and was found to have severe cardiac defects from a heart attack likely to have occurred in the womb. With a large ...

About Us

Editorial Policy

Advertising

Contact Us

eNewsletters

Contribute

Career Center

MashupMD

Blood Cancers Today

Cancer Nursing Today

GU Oncology Now

Urban Health Today

Bile Duct Cancer

Colorectal Cancer

Gastroesophageal Cancer

Gastric Cancer

GEP-NETs

GIST

Liver Cancer

Pancreatic Cancer

GI Oncology Now

Anemia

Deep Vein Thrombosis

Essential Thrombocythemia

Hemophilia

Immune Thrombocytopenic Purpura

Myelodysplastic Syndromes

Myelofibrosis

Myeloproliferative Neoplasms

Polycythemia Vera

Pulmonary Embolism

Sickle Cell Disease

Thrombocytopenia

Thrombophilia

Thrombosis

Thrombotic Thrombocytopenic Purpura

Venous Thromboembolism

von Willebrand Disease

Heme Today

Acute Kidney Injury

ADPKD

Anemia and Kidney Disease

Chronic Kidney Disease

COVID-19 and Kidney Disease

Diabetes and Hypertension

End-Stage Renal Disease

Gout

Hyperkalemia

IgAN

Kidney Transplantation

Metabolic Acidosis

Nephrology Times

HER2 Breast Cancer

Triple-Negative Breast Cancer

Genetics & Breast Cancer

Breast Cancers Today

Atherosclerotic Disease

Atrial Fibrillation

Heart Failure

Hypertension

Interventional Cardiology

Lipid Management

Practice Tips With Dr. Lichaa

Preventive Cardiology

Stroke

Breast Cancer

Gynecologic Cancer

Head and Neck Cancer

Skin Cancer

Oncology

Sleep

Urology

Diabetes

Ophthalmology

— Demodex Blepharitis

Neurology

Rheumatology

Gastroenterology

Pulmonology

Infectious Diseases

— HIV

Health and Wellness

Lupus

Future of Medicine

Orthopedics

Pharmacology

Career News

More

Conferences

CardioNerds

The Sleep Source With Dr. Morse

Rheumatology Rounds With Dr. Maheswaranathan

Partners

Expert Interviews

Subscribe