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<p>Antibiotic use is associated with an increased risk for suffering a heart attack, as well as stroke, in women.<p>The new study <a href="https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehz231/5477431">published</a> in the <em>European Heart Journal</em> included 36,429 women who were initially free of cardiovascular disease (CVD) and cancer in the Nurses&rsquo; Health Study. The researchers estimated hazard ratios for the CVD (a composite of coronary heart disease or stroke) according to the age of antibiotic use (young age, 20-39; middle age, 40-59; and late age, 60 and older) adulthood. Average follow-up was 7.6 years. A total of 1,056 <a href="https://www.docwirenews.com/docwire-pick/cardiology-picks/diet-drinks-stroke-risk/">women</a> developed CVD during the study period.</p><div class="center-image">
<div style="width: 448px" class="wp-caption alignright"><img loading="lazy" decoding="async" src="https://mumcdnstorage.blob.core.windows.net/dwnews//multimedia_prod/pub/web/199022_web.jpg" alt="Do Antibiotics Increase Stroke and Heart Attack Risk in Women?" width="438" height="307">
<p class="wp-caption-text"><em>Credit: European Heart Journal and Prof. Lu Qi of Tulane University</em></p>
</div>
</div><p>According to the results, women who used antibiotics long-term (for two months or more) in late adulthood were at a significantly increased risk of CVD (HR=1.32; 95% CI, 1.03 to 1.70) compared to those who did not use antibiotics regularly late in life (see Graphic). The was after adjustment for covariates like demographics, diet and lifestyle, overuse reasons, obesity, disease status, and use of other medications. Antibiotic use in young adulthood was not significantly associated with incidence of CVD. The researchers wrote that their findings were not influenced by the presence of other major disease, or by medication usage.</p><div class="center-image"></div><p>In a <a href="https://www.eurekalert.org/pub_releases/2019-04/esoc-aul042319.php">press release</a> about the study, Professor Lu Qi, director of the Tulane University Obesity Research Centre at Tulane University in New Orleans, and an adjunct professor of nutrition at Harvard T.C. Chan School of Public Health, Boston, said that one possible reason for the link could be that antibiotics alter the balance of the gut micro-environment, thereby destroying&nbsp; probiotic bacteria and increasing virus prevalence, or the presence of other disease-causing agents.</p><p>&ldquo;Antibiotic use is the most critical factor in altering the balance of microorganisms in the gut. Previous studies have shown a link between alterations in the microbiotic environment of the gut and inflammation and narrowing of the blood vessels, stroke and heart disease,&rdquo; Prof. Qi said in the press release.</p><p>&nbsp;</p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">"Longer duration of exposure to antibiotics in the middle and older adulthood was related to an increased risk of future CVD events among elderly women at usual risk."<br>Reference<a href="https://t.co/XN7HSfJKpn">https://t.co/XN7HSfJKpn</a></p>
<p>&mdash; Stavros Saripanidis, MD (@DrSaripanidis) <a href="https://twitter.com/DrSaripanidis/status/1121693135891861505?ref_src=twsrc%5Etfw">April 26, 2019</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr"><a href="https://twitter.com/hashtag/Antibiotic?src=hash&amp;ref_src=twsrc%5Etfw">#Antibiotic</a> use is linked to increased risk of <a href="https://twitter.com/hashtag/heartattack?src=hash&amp;ref_src=twsrc%5Etfw">#heartattack</a> and <a href="https://twitter.com/hashtag/stroke?src=hash&amp;ref_src=twsrc%5Etfw">#stroke</a>. Read the full article in EHJ <a href="https://twitter.com/ESC_Journals?ref_src=twsrc%5Etfw">@ESC_Journals</a> <a href="https://t.co/WpQHidqIfk">https://t.co/WpQHidqIfk</a> <a href="https://t.co/6Lsx0ZZpda">pic.twitter.com/6Lsx0ZZpda</a></p>
<p>&mdash; OUP Medicine (@OUPMedicine) <a href="https://twitter.com/OUPMedicine/status/1122444640454447104?ref_src=twsrc%5Etfw">April 28, 2019</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p><blockquote class="twitter-tweet" data-width="500" data-dnt="true">
<p lang="en" dir="ltr">Antibiotic use linked to long-lasting alterations in the gut and future heart disease.  <a href="https://t.co/i21QDPky4l">https://t.co/i21QDPky4l</a></p>
<p>&mdash; PatFTerry (@PatFTerry) <a href="https://twitter.com/PatFTerry/status/1121364966668472321?ref_src=twsrc%5Etfw">April 25, 2019</a></p>
</blockquote><p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script></p></p>


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Do Antibiotics Increase Stroke and Heart Attack Risk in Women?

Cardiology

Antibiotic use is associated with an increased risk for suffering a heart attack, as well as stroke, in women. ...

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