The IMPLEMENT-HF initiative, led by the American Heart Association, significantly increased the use of guideline-directed quadruple medical therapy (QMT) for patients hospitalized with heart failure with reduced ejection fraction (HFrEF). Over two years, QMT usage rose from 4.7% to 44.6% at discharge and from 0% to 44.8% at 30 days post-discharge across 85 hospitals. The initiative used structured interventions, hospital-specific performance feedback, and social needs assessments to overcome barriers to care. These results demonstrate that system-level, collaborative strategies can dramatically improve evidence-based heart failure treatment.