PDIGREE: New Insights on Tolerability, Treatment Response of 1L Ipi/Nivo for mccRCC
PDIGREE: New Insights on Tolerability, Treatment Response of 1L Ipi/Nivo for mccRCC

Tian Zhang, MD, UT Southwestern Medical Center, gives an update on the PDIGREE trial, including new information on tolerability and treatment response to first-line ipi/nivo for patients with metastatic clear cell renal cell carcinoma.

She comments on differential clinical or radiographic response patterns that might inform early identification of non-responders, as well as how she sees this trial informing treatment decisions in intermediate- or poor-risk patients.

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Latest News

Utilizing AI to Determine ARPI Benefit for Non-Metastatic Prostate Cancer in the STAMPEDE Trial
Utilizing AI to Determine ARPI Benefit for Non-Metastatic Prostate Cancer in the STAMPEDE Trial
Nicholas James, PhDLocalized | June 9, 2025
Dr. James showcases an MMAI model to identify benefit from 2nd-generation ARPIs in hr/nm PCa patients from STAMPEDE.
SURE-02: Neoadjuvant Sacituzumab Govitecan Plus Pembrolizumab, Response-Adapted Bladder Sparing, and Adjuvant Pembrolizumab for Patients With MIBC
SURE-02: Neoadjuvant Sacituzumab Govitecan Plus Pembrolizumab, Response-Adapted Bladder Sparing, and Adjuvant Pembrolizumab for Patients With MIBC
Andrea Necchi, MDMuscle Invasive Urothelial Carcinoma | June 9, 2025
Drs. Necchi and Tawagi break down in detail the first results of SURE-02 in patients with muscle-invasive bladder cancer.
AMPLITUDE Demonstrates Extended Radiographic PFS With Addition of Niraparib to Abiraterone in HRR-altered mCSPC
AMPLITUDE Demonstrates Extended Radiographic PFS With Addition of Niraparib to Abiraterone in HRR-altered mCSPC
Lauren Dembeck, PhDmCSPC | June 9, 2025
Adding niraparib to abiraterone and prednisone prolongs rPFS in patients with mCSPC harboring HRR gene alterations.
CLONEVO: Preoperative Abemaciclib for Cisplatin-Ineligible MIBC With Molecular Response Assessment
CLONEVO: Preoperative Abemaciclib for Cisplatin-Ineligible MIBC With Molecular Response Assessment
Bishoy Faltas, MDMuscle Invasive Urothelial Carcinoma | June 6, 2025
Dr. Faltas highlights CLONEVO, a trial using preoperative abemaciclib in cisplatin-ineligible MIBC with ctDNA monitoring.
Efficacy, Safety of Mitomycin Plus BCG for Patients With High-Risk Non-Muscle Invasive Bladder Cancer
Efficacy, Safety of Mitomycin Plus BCG for Patients With High-Risk Non-Muscle Invasive Bladder Cancer
Dickon Hayne, MDNon-Muscle Invasive Urothelial Carcinoma | June 6, 2025
Dr. Hayne speaks about the ANZUP 101 trial results that evaluated the combination of mitomycin and BCG for NMIBC.
Prognostic Significance of PSA>0.2 After 6-12 Months of Treatment for mHSPC Intensified by ARPI: A Real-World Analysis
Prognostic Significance of PSA>0.2 After 6-12 Months of Treatment for mHSPC Intensified by ARPI: A Real-World Analysis
Michael Ong, MDmCSPC | June 6, 2025
Drs. Ong and Roy detail a multinational real-world analysis of the IRONMAN registry on the significance of PSA>0.2.
EVOLUTION: Lu-PSMA With Ipi/Nivo in mCRPC
EVOLUTION: Lu-PSMA With Ipi/Nivo in mCRPC
Scott Tagawa, MD, MS, FACPRLT | June 5, 2025
Dr. Tagawa explains the rationale for EVOLUTION, a phase II analysis of Lu-PSMA-617 with ipilimumab and nivolumab in mCRPC.
TheraP: Clonal Hematopoiesis in mCRPC Patients Receiving Lu-PSMA or Cabazitaxel
TheraP: Clonal Hematopoiesis in mCRPC Patients Receiving Lu-PSMA or Cabazitaxel
Scott Tagawa, MD, MS, FACPRLT | June 5, 2025
Dr. Tagawa contextualizes a post hoc analysis on clonal hematopoiesis in those who received 177Lu-PSMA-617 or cabazitaxel.
ProstACT GLOBAL: TLX591 and Best SOC for Patients With PSMA-Expressing mCRPC
ProstACT GLOBAL: TLX591 and Best SOC for Patients With PSMA-Expressing mCRPC
Scott Tagawa, MD, MS, FACPRLT | June 5, 2025
Dr. Tagawa showcases the ProstACT Global trial, a phase III study of 177Lu-rosptamab in patients with mCRPC.
VIOLET: Terbium-161 Radioligand Treatment in Patients With mCRPC
VIOLET: Terbium-161 Radioligand Treatment in Patients With mCRPC
Scott Tagawa, MD, MS, FACPRLT | June 5, 2025
Dr. Tagawa breaks down the VIOLET study, a single-arm phase I/II first-in-human results of terbium-161Tb-PSMA-I&T.
KEYNOTE-564 Follow-Up Leading to the STRIKE Trial
KEYNOTE-564 Follow-Up Leading to the STRIKE Trial
Brad McGregor, MDAdvanced Renal Cell Carcinoma | June 5, 2025
Dr. McGregor shares the opening of the STRIKE trial, which investigates adding tivo to pembro in the mRCC adjuvant setting.
ARC-20: Casdatifan Plus Cabozantinib Expansion Cohort
ARC-20: Casdatifan Plus Cabozantinib Expansion Cohort
Brad McGregor, MDAdvanced Renal Cell Carcinoma | June 5, 2025
Dr. McGregor opens up about the expansion cohort of the phase 1 ARC-20 study, which looked at casdatifan plus cabozantinib.
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Editorial Advisory Board
Brian Rini, MD, FASCO
Brian Rini, MD, FASCOEditor | Chief of Clinical Trials at Vanderbilt-Ingram Cancer Center
Thomas Powles, MBBS, MRCP, MD
Thomas Powles, MBBS, MRCP, MDEditor | Director, Barts Cancer Centre at St. Bartholomew's Hospital
Katy Beckermann, MD, PhD
Katy Beckermann, MD, PhDEditor | Medical Director of GU Clinical Research at Tennessee Oncology
Christopher Wallis, MD, PhD, FRCSC
Christopher Wallis, MD, PhD, FRCSCAssistant Professor of Urology | University of Toronto
Akhil Abraham Saji, MD
Akhil Abraham Saji, MDEditor | Urologist at Swedish Health Services
David Ambinder, MD
David Ambinder, MDEditor | Urology Resident at New York Medical College/Westchester Medical Center

The Uromigos Live and Unplugged 2024

The Uromigos Live & Unplugged 2024
The Uromigos Live & Unplugged 2024

The Uromigos Live & Unplugged 2024 took place September 27-29 in Nashville, Tennessee.

This meeting was the third annual in-person event hosted by Thomas Powles, MD, and Brian Rini, MD, FASCO, in partnership with Mashup Media, featuring expert panels and audience discussion around the latest data in genitourinary oncology and vision for the future.

Expert Interviews

Teaching TURBT Over 5G: Integrating XR Headsets Into Urologic Practice
Teaching TURBT Over 5G: Integrating XR Headsets Into Urologic Practice
Evan Kovac, MDProstate Cancer | May 19, 2025
Dr. Evan Kovac speaks about his pioneering work with extended reality display technology in urologic surgery and education.
Bladder Cancer Without Cystectomy: Dr. Alexandre Zlotta on the Maturation of Trimodality Therapy
Bladder Cancer Without Cystectomy: Dr. Alexandre Zlotta on the Maturation of Trimodality Therapy
Alexandre Zlotta, MDMuscle Invasive Urothelial Carcinoma | May 15, 2025
Dr. Zlotta discusses the current state and future of bladder-sparing therapy in MIBC, including how to best select patients.
From VEGF to HIF-2 Targeting Drugs: Dr. James Brugarolas’ Journey to Transforming Kidney Cancer Treatment
From VEGF to HIF-2 Targeting Drugs: Dr. James Brugarolas’ Journey to Transforming Kidney Cancer Treatment
James “Jim” Brugarolas, MD, PhDRenal Cell Carcinoma | April 22, 2025
Dr. Brugarolas reflects on his lab's role in developing HIF-2 inhibitors and his ongoing work to improve patient outcomes.
Bladder-Sparing Innovations in MIBC: Dr. Elizabeth Plimack on the RETAIN Approach and Its Future
Bladder-Sparing Innovations in MIBC: Dr. Elizabeth Plimack on the RETAIN Approach and Its Future
Elizabeth Plimack, MD, MS, FASCOMuscle Invasive Urothelial Carcinoma | March 17, 2025
Dr. Plimack details RETAIN, from early findings with neoadjuvant ddMVAC to the evolution of RETAIN-1 and RETAIN-2.
Precision in Prostate Cancer: Dr. Amir Lebastchi on Tailoring Focal Therapy for Optimal Outcomes
Precision in Prostate Cancer: Dr. Amir Lebastchi on Tailoring Focal Therapy for Optimal Outcomes
Akhil Abraham Saji, MDLocalized | January 14, 2025
Drs. Saji and Lebastchi explore focal therapy, covering its historical evolution, techniques, and energy modalities.
Ahmed E. Ghazi – Revolutionizing and Scaling Surgical Training Through Simulation Models
Ahmed E. Ghazi – Revolutionizing and Scaling Surgical Training Through Simulation Models
David Ambinder, MDLocalized | January 6, 2025
Dr. Ghazi is recognized as a pioneer in patient-specific surgical simulation, using state-of-the-art techniques in surgery.

Conference Coverage

Live meeting highlights

Utilizing AI to Determine ARPI Benefit for Non-Metastatic Prostate Cancer in the STAMPEDE Trial
Nicholas James, PhDLocalized | June 9, 2025
Dr. James showcases an MMAI model to identify benefit from 2nd-generation ARPIs in hr/nm PCa patients from STAMPEDE.
View More
SURE-02: Neoadjuvant Sacituzumab Govitecan Plus Pembrolizumab, Response-Adapted Bladder Sparing, and Adjuvant Pembrolizumab for Patients With MIBC
Andrea Necchi, MDMuscle Invasive Urothelial Carcinoma | June 9, 2025
Drs. Necchi and Tawagi break down in detail the first results of SURE-02 in patients with muscle-invasive bladder cancer.
View More
AMPLITUDE Demonstrates Extended Radiographic PFS With Addition of Niraparib to Abiraterone in HRR-altered mCSPC
Lauren Dembeck, PhDmCSPC | June 9, 2025
Adding niraparib to abiraterone and prednisone prolongs rPFS in patients with mCSPC harboring HRR gene alterations.
Read More
CLONEVO: Preoperative Abemaciclib for Cisplatin-Ineligible MIBC With Molecular Response Assessment
Bishoy Faltas, MDMuscle Invasive Urothelial Carcinoma | June 6, 2025
Dr. Faltas highlights CLONEVO, a trial using preoperative abemaciclib in cisplatin-ineligible MIBC with ctDNA monitoring.
View More

Video Insights

Clinical discussions with experts in the field

Network Websites

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